Understanding and treating airway issues in critically ill patients on mechanical ventilation
Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients
This study is testing a new way to monitor and improve breathing for critically ill patients on ventilators to see if it helps them get better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Southeast University, China Academic / other |
| Locations | 1 site (Nanjing, Jiangsu) |
| Trial ID | NCT06393179 on ClinicalTrials.gov |
What this trial studies
This study focuses on the challenges of monitoring airway pressure in critically ill patients who are mechanically ventilated. It aims to differentiate between airway closure and alveolar collapse using a quasi-static pressure-volume curve and electrical impedance tomography (EIT) to improve ventilation strategies. By assessing these conditions, the study seeks to optimize mechanical ventilation settings for better patient outcomes. The intervention involves a low-flow insufflation technique to gather data on lung behavior during ventilation.
Who should consider this trial
Good fit: Ideal candidates include adult patients undergoing controlled mechanical ventilation with an endotracheal intubation duration of less than 48 hours.
Not a fit: Patients with severe hemodynamic instability or chronic lung diseases requiring long-term oxygen therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved ventilation strategies and outcomes for critically ill patients requiring mechanical ventilation.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in improving mechanical ventilation strategies, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients undergoing controlled mechanical ventilation * The duration of endotracheal intubation \< 48 hrs Exclusion Criteria: * Severe hemodynamic instability * Severe chronic lung disease requiring long-term home oxygen therapy * Patients without analgesic sedation * Decline to participate in the study * Refusal to sign informed consent
Where this trial is running
Nanjing, Jiangsu
- Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University — Nanjing, Jiangsu, China (Recruiting)
Study contacts
- Principal investigator: ling liu — Zhongda Hospital
- Study coordinator: ling liu, phD
- Email: liulingdoctor@126.com
- Phone: 15901599659
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.