Ultrasound-guided Retrolaminar Block vs TAP Block in Laparoscopic Upper Abdominal Surgery
Official title: Safety and Efficacy of Ultrasound Guided Retrolaminar Block Versus Transverse Abdominis Plane Block on Quality of Recovery in Laparoscopic Upper Abdominal Surgeries: A Randomized Comparative Clinical Trial
Run by Mansoura University · NCT07720817 · Data updated 2026-11-12
This study tests whether retrolaminar block works as well as a TAP block to reduce pain and opioid use after laparoscopic upper abdominal surgery in adults aged 21–65.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years to 65 Years |
| Sex | All |
| Enrollment | 164 (estimated) |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Al Mansurah, Dakahlia Governorate) |
| Status | Recruiting |
| Started | July 1, 2026 |
| Main results expected | January 2027 |
| Study ends | February 2027 |
| Registry record updated | September 16, 2026 |
| Trial ID | NCT07720817 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 21–65 years old, ASA I–II, BMI < 30 kg/m², undergoing elective laparoscopic upper abdominal surgery under general anesthesia.
✕Probably not a fit
Patients with allergy to study drugs, coagulation abnormalities or infection at the block site, emergency surgeries, or significant comorbidities may not benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares two ultrasound-guided nerve blocks to manage postoperative pain after laparoscopic upper abdominal procedures. Adults aged 21 to 65 with ASA I–II and BMI under 30 kg/m² undergoing elective surgery are randomized to receive either a retrolaminar block or a TAP block. The aim is to determine safety and analgesic effectiveness, with the expectation that blocking the abdominal wall nerves will reduce opioid requirements and related side effects. The trial is conducted at Mansoura University, with the primary focus on short-term postoperative pain control and analgesic consumption. No collaborator sites are listed beyond the lead sponsor.
Why it matters
Potential benefit: If successful, patients may experience better pain control with fewer opioids after surgery, potentially leading to quicker recovery and shorter hospital stays.
How similar studies have gone: Ultrasound-guided abdominal nerve blocks are established tools for multimodal analgesia, with prior evidence supporting safety and effectiveness, though direct head-to-head comparisons like this are less common.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 21 and 65 years. * American Society of Anesthesiologists (ASA) physical status I or II. * Body mass index (BMI) less than 30 kg/m². * Scheduled for elective laparoscopic upper abdominal surgery under general anesthesia. Exclusion Criteria: * Refusal to participate in the study. * Known allergy or hypersensitivity to any of the study drugs. * Infection at the planned block insertion site. * Severe uncontrolled cardiac, renal, hepatic, neurological, or respiratory disease. * Pre-existing chronic pain. * Immunodeficiency. * Coagulation abnormalities, anticoagulant therapy, or platelet count less than 80,000/µL. * Emergency surgery.
Where it's running
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Mansoura University
Al Mansurah, Dakahlia Governorate, Egypt Recruiting
Study contacts
- Study coordinator: mohamed elnagar Mohamed A. Elnagar MB BCh, MB BCh
- Email: melnaggar789@gmail.com
- Phone: +20 1009344804
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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We will test whether an M‑TAPA block or a TAP block gives better pain relief after elective unilateral open inguinal hernia surgery in adults aged 18–65.
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Erector spinae plane block for pain after laparoscopic abdominal surgery
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This study will test whether giving a TAP block or squirting local anesthetic onto the liver during elective keyhole gallbladder removal reduces post-operative pain in adults.
-
Peripheral autonomic plus TAP blocks for pain after minimally invasive left-sided colorectal surgery
This will try adding a peripheral autonomic block (targeting the superior hypogastric and inferior mesenteric plexuses) plus a TAP block to standard pain control in adults having elective minimally invasive left-sided colorectal surgery to see if it reduces pain and opioid use in the first 48 hours.
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This compares two nerve-block techniques to see which gives better pain relief after laparoscopic gallbladder removal for adults aged 18-65.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.