Ultrasound evaluation for children with their first urinary tract infection
Is Ultrasonography Mandatory in All Children at Their First Febrile Urinary Tract Infection?
This study is testing whether kidney ultrasounds are needed for all children with their first urinary tract infection or just for those with certain risk factors.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 2 Months to 3 Years |
| Sex | All |
| Sponsor | IRCCS Burlo Garofolo Academic / other |
| Drugs / interventions | radiation |
| Locations | 3 sites (Florence and 2 other locations) |
| Trial ID | NCT05814250 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the role of kidney ultrasound (KUS) in children experiencing their first febrile urinary tract infection (fUTI). It examines whether routine KUS is necessary for all children or if it should be reserved for those with specific risk factors, given that current guidelines are not based on strong evidence. The study will include children who have had their first episode of fUTI and will undergo KUS, while excluding those with prior UTIs or known kidney anomalies. The findings could help refine guidelines for the management of fUTIs in pediatric patients.
Who should consider this trial
Good fit: Ideal candidates are children experiencing their first episode of febrile urinary tract infection who are scheduled for kidney ultrasound.
Not a fit: Patients with previous urinary tract infections or known congenital anomalies of the kidney and urinary tract may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more tailored and effective management strategies for children with febrile urinary tract infections.
How similar studies have performed: Other studies have suggested varying approaches to the use of kidney ultrasound in similar contexts, indicating that this area is still under investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Patient with first episode of fUTI that subsequently do KUS. Exclusion Criteria: * patients with previous episodes of UTIs * patients on antibiotic prophylaxis * previous finding of malformative uropathies or cystic disease * prenatal diagnosis of CAKUT with the following parameters: Presence of oligohydramnios, alterations in renal number, location and echo structure, bladder alteration, dilations of the renal pelvis and ureters
Where this trial is running
Florence and 2 other locations
- AOU Meyer IRCCS — Florence, Italy (Recruiting)
- IRCCS Policlinico Cà Granda — Milan, Italy (Recruiting)
- IRCCS materno infantile Burlo Garofolo — Trieste, Italy (Recruiting)
Study contacts
- Study coordinator: Marco Pennesi, MD
- Email: marco.pennesi@burlo.trieste.it
- Phone: +39 040.3785.263
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.