Post-Emergency Antibiotic Optimization for UTI
Official title: Post-Emergency Optimization of UTI Antibiotic Therapy: "Fluoroquinolones and Third-Generation Cephalosporins Under the Spotlight"
Run by Centre Hospitalier Intercommunal Creteil · NCT07559318 · Data updated 2026-11-12
In people who come to the emergency department with a suspected urinary tract infection, this study looks at how doctors can adjust antibiotic therapy after urine culture results to use the right antibiotic and reduce overuse.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 330 (estimated) |
| Sponsor | Centre Hospitalier Intercommunal Creteil Academic / other |
| Locations | 3 sites (Melun and 2 other locations) |
| Status | Recruiting |
| Started | June 1, 2026 |
| Main results expected | January 1, 2027 |
| Study ends | January 1, 2027 |
| Registry record updated | August 26, 2026 |
| Trial ID | NCT07559318 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years and older presenting to participating EDs with symptoms of an outpatient-appropriate UTI who have had a urine culture taken.
✕Probably not a fit
Patients with severe UTIs or sepsis requiring inpatient care are excluded, so they may not benefit from optimization in this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, multicenter, non-interventional study conducted over six months focusing on emergency department presentations of suspected UTIs managed as outpatients. Treatments begun in the ED may be adjusted 48–72 hours after inclusion based on urine culture and susceptibility results. The goal is to optimize antibiotic choices to balance effective care with antimicrobial stewardship, reducing broad-spectrum usage where narrower agents are appropriate. Data will come from patients discharged with or without empiric antibiotics, with follow-up to reassess and modify prescriptions as needed. The study aims to inform practice on de-escalation and stewardship in outpatient UTI management.
Why it matters
Potential benefit: If successful, the study could improve antibiotic prescribing by favoring narrow-spectrum agents when appropriate, helping to reduce resistance and side effects.
How similar studies have gone: Previous antimicrobial stewardship efforts in UTIs support de-escalation and targeted therapy, but this study adds real-world, ED-based observational data for outpatient management.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or over * Patients presenting at emergency department, with symptoms suggestive of a urinary tract infection suitable for outpatient management (uncomplicated cystitis or cystitis at risk of complications, uncomplicated pyelonephritis or pyelonephritis at risk of complications, male urinary tract infection with or without fever) who have had a urine culture taken Exclusion Criteria: * Refusal to participate in the study * Vulnerable person (person under guardianship or trusteeship, minor, person deprived of liberty, person unable to express their refusal) * Pregnant women * Severe urinary tract infection (sepsis, septic shock or requiring drainage, except for low urinary catheterisation) * Hospitalisation for a urinary tract infection or decompensation of another comorbidity * Suspected urinary tract infection without a urine culture having been performed
Where it's running
-
Chiv
Villeneuve-Saint-Georges, France Recruiting -
Ghsif
Melun, France Not yet recruiting -
CH St denis
Saint-Denis, France Not yet recruiting
Study contacts
- Study coordinator: Anna BELKACEM, MD
- Email: anna.belkacem@chiv.fr
- Phone: 01 43 86 21 62
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.