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Clinical trial Recruiting at 2 sites Interventional Ages 18 to 40

Two versus four custom 3D titanium plates for upper jaw repositioning

Official title: Accuracy of Maxillary Two Customized 3D Titanium Miniplates Versus Four Customized 3D Miniplates for Virtual Plan Transfer in Orthognathic Surgery. Randomized Clinical Trial.

Run by Cairo University · NCT07418684 · Data updated 2026-11-12

This test sees if using two custom 3D titanium plates instead of four gives equally accurate virtual-plan transfer for people having orthognathic (jaw) surgery.

Quick facts

Study typeInterventional
Ages18 Years to 40 Years
SexAll
Enrollment10 (estimated)
SponsorCairo University
Academic / other
Locations2 sites (Cairo and 1 other locations)
StatusRecruiting
StartedMarch 1, 2025
Main results expectedMarch 1, 2027
Study endsDecember 1, 2027
Registry record updatedOctober 20, 2026
Trial IDNCT07418684 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with dentofacial disharmony who need orthognathic surgery, are medically fit for general anesthesia, have no active TMD, and can attend follow-up visits.

Probably not a fit

Patients with systemic conditions that impair bone healing, active infections or intra-bony lesions, active TMD, or those unwilling/unable to follow up may not benefit or be eligible.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patients will undergo virtual surgical planning and receive patient-specific 3D titanium miniplates designed to match the planned maxillary repositioning. Participants will be fixed with either two or four customized plates in place of traditional wafers, and surgeons will perform the planned osteotomies and repositioning. Postoperative imaging will be used to quantify how closely the actual bone positions match the virtual plan and to compare accuracy between the two groups. The protocol excludes patients with systemic diseases that impair healing, active temporomandibular disorders, intra-bony lesions or infections, or those unfit for general anesthesia.

Why it matters

Potential benefit: If successful, this could allow use of fewer plates while maintaining surgical accuracy, reducing hardware, operating time, and potentially cost.

How similar studies have gone: Previous reports indicate custom 3D plates can improve virtual-plan transfer compared with traditional wafers, but direct comparisons of two versus four maxillary plates are limited.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

.Patients with dentofacial disharmony and misalignment requiring orthognathic surgeries.

* Patients with no signs or symptoms of active TMDs.
* Highly motivated patients.

Exclusion Criteria:

* Patients who refused to be included in the research.
* Patients with systemic diseases that may hinder the normal healing process or render the patient not fitting for general anesthesia.
* Patients with intra-bony lesions or infections that may retard the osteotomy healing.

Where it's running

  • Cairo University
    Cairo, Egypt     Recruiting
  • faculty of dentistry Cairo University
    Cairo, Egypt     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Orthognathic Surgery 11Cairo University 349
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.