Two-step Propofol Dose for Induction to See If It Reduces Injection Pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional phase 4 study investigates a two-step propofol induction strategy in adults undergoing non-cardiac surgery under general anesthesia. The approach uses a small initial bolus (about 20 mg) followed by the remaining dose to see if it reduces injection pain compared with a single bolus. The study will compare pain outcomes and perioperative factors between the two dosing methods. Eligible participants are adults 18 and older without premedication with midazolam and with a 20-g IV catheter for induction. Data collection will occur at the point of induction and during anesthesia recovery to assess pain perception and tolerability.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults ≥18 years old.
* Undergoing non cardiac surgery under general anesthesia.
* Receiving propofol for induction.
* No midazolam premedication
* 20g IV Catheter below the antecubital fossa used for induction of anesthesia

Exclusion Criteria:

* Emergency surgery.
* Inability to communicate (language or cognitive impairment).
* Pre-induction IV analgesia administration or patients under preoperatively
* Patient with dementia, Alzheimer or other uncontrolled psychiatric diseases that would impact their ability to willingly participate

Where it's running

• Hôpital Universitaire de Bruxelles - Hôpital erasme
  Brussels, Belgium Recruiting

Study contacts

• Study coordinator: Denis Schmartz, MD
• Email: denis.schmartz@hubruxelles.be
• Phone: +3225553324

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.