Comparing two methods for frozen embryo transfer in women with regular cycles
Official title: Prospective Randomized Non-Inferiority Study Comparing Natural Cycle Frozen Embryo Transfer (NC-FET) to a New Type of Endometrial Preparation for FET: Natural Proliferative Phase (NPP-FET)
Run by Erasme University Hospital · NCT06859944 · Data updated 2026-11-12
This study is testing a new way to transfer frozen embryos in women with regular cycles to see if it works just as well as the current method while allowing for better planning.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 272 (estimated) |
| Sponsor | Erasme University Hospital Academic / other |
| Locations | 1 site (Brussels) |
| Status | Recruiting |
| Started | August 5, 2024 |
| Main results expected | June 30, 2025 |
| Study ends | June 30, 2026 |
| Registry record updated | March 10, 2025 |
| Trial ID | NCT06859944 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women with regular menstrual cycles who are undergoing a single blastocyst transfer.
✕Probably not a fit
Patients requiring preimplantation genetic diagnosis, using testicular sperm, or donor oocytes may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study compares the effectiveness of Natural Cycle Frozen Embryo Transfer (NC-FET) with a new method called Natural Proliferative Phase Frozen Embryo Transfer (NPP-FET). It aims to demonstrate that NPP-FET is not inferior to NC-FET while offering better planning flexibility. Patients with regular menstrual cycles will undergo monitoring through blood tests and ultrasounds to prepare for embryo transfer. The study will assess pregnancy rates based on HCG levels following the embryo transfer.
Why it matters
Potential benefit: If successful, this study could provide a more flexible and effective approach to frozen embryo transfers, potentially improving pregnancy rates.
How similar studies have gone: Other studies have explored various embryo transfer methods, but the specific approach of NPP-FET is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Single transfer Blastocyste Exclusion Criteria: * PGT (Preimplantation genetic diagnosis) * Testicular Sperm * Donor oocytes
Where it's running
-
Hopital Erasme
Brussels, Belgium Recruiting
Study contacts
- Study coordinator: Anne Delbaere
- Email: anne.delbaere@hubruxelles.be
- Phone: +32 2 555 45 70
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.