Clinical trial Recruiting at 1 site Observational Ages 18 to 45 Women only

Comparing two methods for frozen embryo transfer in women with regular cycles

Official title: Prospective Randomized Non-Inferiority Study Comparing Natural Cycle Frozen Embryo Transfer (NC-FET) to a New Type of Endometrial Preparation for FET: Natural Proliferative Phase (NPP-FET)

Run by Erasme University Hospital · NCT06859944 · Data updated 2026-11-12

This study is testing a new way to transfer frozen embryos in women with regular cycles to see if it works just as well as the current method while allowing for better planning.

Quick facts

Study typeObservational
Ages18 Years to 45 Years
SexWomen only
Enrollment272 (estimated)
SponsorErasme University Hospital
Academic / other
Locations1 site (Brussels)
StatusRecruiting
StartedAugust 5, 2024
Main results expectedJune 30, 2025
Study endsJune 30, 2026
Registry record updatedMarch 10, 2025
Trial IDNCT06859944 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are women with regular menstrual cycles who are undergoing a single blastocyst transfer.

Probably not a fit

Patients requiring preimplantation genetic diagnosis, using testicular sperm, or donor oocytes may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares the effectiveness of Natural Cycle Frozen Embryo Transfer (NC-FET) with a new method called Natural Proliferative Phase Frozen Embryo Transfer (NPP-FET). It aims to demonstrate that NPP-FET is not inferior to NC-FET while offering better planning flexibility. Patients with regular menstrual cycles will undergo monitoring through blood tests and ultrasounds to prepare for embryo transfer. The study will assess pregnancy rates based on HCG levels following the embryo transfer.

Why it matters

Potential benefit: If successful, this study could provide a more flexible and effective approach to frozen embryo transfers, potentially improving pregnancy rates.

How similar studies have gone: Other studies have explored various embryo transfer methods, but the specific approach of NPP-FET is relatively novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Single transfer Blastocyste

Exclusion Criteria:

* PGT (Preimplantation genetic diagnosis)
* Testicular Sperm
* Donor oocytes

Where it's running

  • Hopital Erasme
    Brussels, Belgium
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.