Comparing two methods for frozen embryo transfer in women with regular cycles
Prospective Randomized Non-Inferiority Study Comparing Natural Cycle Frozen Embryo Transfer (NC-FET) to a New Type of Endometrial Preparation for FET: Natural Proliferative Phase (NPP-FET)
This study is testing a new way to transfer frozen embryos in women with regular cycles to see if it works just as well as the current method while allowing for better planning.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 272 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | Erasme University Hospital Academic / other |
| Locations | 1 site (Brussels) |
| Trial ID | NCT06859944 on ClinicalTrials.gov |
What this trial studies
This study compares the effectiveness of Natural Cycle Frozen Embryo Transfer (NC-FET) with a new method called Natural Proliferative Phase Frozen Embryo Transfer (NPP-FET). It aims to demonstrate that NPP-FET is not inferior to NC-FET while offering better planning flexibility. Patients with regular menstrual cycles will undergo monitoring through blood tests and ultrasounds to prepare for embryo transfer. The study will assess pregnancy rates based on HCG levels following the embryo transfer.
Who should consider this trial
Good fit: Ideal candidates are women with regular menstrual cycles who are undergoing a single blastocyst transfer.
Not a fit: Patients requiring preimplantation genetic diagnosis, using testicular sperm, or donor oocytes may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a more flexible and effective approach to frozen embryo transfers, potentially improving pregnancy rates.
How similar studies have performed: Other studies have explored various embryo transfer methods, but the specific approach of NPP-FET is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Single transfer Blastocyste Exclusion Criteria: * PGT (Preimplantation genetic diagnosis) * Testicular Sperm * Donor oocytes
Where this trial is running
Brussels
- Hopital Erasme — Brussels, Belgium (Recruiting)
Study contacts
- Study coordinator: Anne Delbaere
- Email: anne.delbaere@hubruxelles.be
- Phone: +32 2 555 45 70
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.