TWEAK biomarker in MS: a blood test to see if inflammatory relapses are coming

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study measures circulating TWEAK levels in people with multiple sclerosis to see if fluctuations correlate with upcoming inflammatory attacks. Blood samples will be collected over the first year to analyze associations with relapse events. The goal is to determine if TWEAK concentration changes can serve as an early biomarker to guide monitoring and treatment decisions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* a first episode of inflammation and demyelination of the central nervous system affecting the optic nerve, the spinal cord, one cerebral hemisphere, or the brainstem; or confirmed multiple sclerosis
* no differential diagnosis at enrollment based on clinical examination and laboratory tests
* compliance with the revised 2017 Mac Donald diagnostic criteria

Exclusion Criteria:

* age \<18 years old
* person in an emergency situation
* adult who is subject to a legal protection measure (an adult under guardianship, conservatorship, or judicial protection), or who is unable to give consent
* not Enrolled in a Social Security Program
* pregnant or breastfeeding woman

Where it's running

• Assistance Publique Hopitaux de Marseille
  Marseille, France Recruiting

Study contacts

• Study coordinator: Sophie DESPLAT-JEGO
• Email: sophie.jego-desplat@ap-hm.fr
• Phone: + 33 4 91 38 39 07

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.