Clinical trial Recruiting at 1 site Interventional Ages 9 to 15

Trying new brain stimulation to help ADHD symptoms

Official title: Finding Alternatives to Standard Treatment for Attention-Deficit Hyperactivity Disorder

Run by University of Calgary · NCT04532190 · Data updated 2026-11-12

This study tests whether theta burst repetitive transcranial magnetic stimulation (rTMS) to the right prefrontal cortex can reduce ADHD symptoms in children aged 9–15.

Quick facts

Study typeInterventional
Ages9 Years to 15 Years
SexAll
Enrollment30 (estimated)
SponsorUniversity of Calgary
Academic / other
Locations1 site (Calgary, Alberta)
StatusRecruiting
StartedMarch 1, 2026
Main results expectedDecember 31, 2027
Study endsDecember 31, 2027
Registry record updatedMay 14, 2026
Trial IDNCT04532190 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are youths aged 9–15 with ADHD, IQ above 80, fluent in English, and on a stable ADHD medication regimen for at least 3 months if applicable.

Probably not a fit

Participants with certain comorbidities (e.g., autism spectrum disorder) or contraindications to MRI/TMS may not experience benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This open-label study will apply theta burst rTMS to the right prefrontal cortex over four weeks (five sessions per week) to see if ADHD symptoms improve. Participants will undergo baseline MRI and neuropsychological assessments, receive the brain stimulation, then have post-intervention testing and MRI. The goal is to determine whether non-invasive brain stimulation can produce measurable improvements in attention and related behaviors for youths with ADHD. Results will inform feasibility and potential signal of benefit in this population.

Why it matters

Potential benefit: If successful, participants may experience reduced ADHD symptoms and improved attention after non-invasive brain stimulation.

How similar studies have gone: Prior research in adolescents suggests rTMS may reduce ADHD symptoms, but evidence remains limited and this study explores feasibility in a pediatric open-label context.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Diagnosis of ADHD
2. 9-15 years old
3. IQ greater than 80
4. English fluency (to enable consent/assent)
5. If on medication, must have been on the same type and dosage for at least 3 months.

Exclusion Criteria:

1. Diagnosis of mania, psychosis, or bipolar disorder
2. Impediments to TMS or MRI (i.e. metal implants in body)
3. Prior electroconvulsive therapy or vagus nerve stimulation
4. Diagnosis of Autism Spectrum Disorder.

Where it's running

  • Alberta Children's Hospital
    Calgary, Alberta, Canada
    Recruiting

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.