Transplanting stem cells and grafting testicular tissue to restore male fertility

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the safety and feasibility of spermatogonial stem cell transplantation and testicular tissue grafting in men who have previously cryopreserved testicular tissue due to infertility risks from cancer treatments. Participants will undergo ultrasound-guided injection of testicular cells or grafting of testicular tissue to restore sperm production. The study focuses on men who are in Tanner stage 3 or higher and have completed their primary treatment for conditions that risk fertility. By utilizing previously frozen testicular tissues, the study seeks to provide innovative solutions for male infertility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male participant at least in Tanner stage 3
* Previously cryopreserved and stored testicular tissue/cells (frozen due to an infertility-risking diagnosis or treatment such as chemotherapy or radiation) available for autologous transplantation and grafting
* Healthy enough to undergo anesthesia
* Written clearance for the procedure from the patient's hematologist or oncologist to confirm the patient has finished treatment for primary condition and are clear to undergo autologous stem cell transplant

Exclusion Criteria:

* Participants considered to be high risk for surgical complications
* Participants with a history of leukemia, lymphoma or testicular cancer or a cancer that likely involved testicles at the time of testicular tissue collection
* Diagnosed with psychological, psychiatric, or other conditions which prevent giving fully informed consent.

Where it's running

• Magee-Womens Hospital
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Kyle E Orwig, PhD — University of Pittsburgh
• Study coordinator: Jennifer L Anglin
• Email: fertilitypreservation@upmc.edu
• Phone: 412-641-7475

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.