Transplanting gut bacteria to improve outcomes in organ transplant patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the efficacy and safety of washed microbiota transplantation (WMT) in patients who have undergone solid organ transplantation and are experiencing gastrointestinal complications. The study focuses on restoring gut microbiome balance, which may be disrupted due to immunosuppressive therapies and antibiotics. By utilizing a new methodology for fecal microbiota transplantation, the researchers aim to address common post-transplant complications such as diarrhea and infections. Participants will be solid organ transplant recipients willing to undergo this innovative treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. solid organ transplantation recipients;
2. suffering from gastrointestinal symptoms (e.g. diarrhea, constipation, abdominal pian), infection (e.g. Clostridium difficile) post-transplantation and so on;
3. is willing to undergo WMT and provide written informed consent.

Exclusion Criteria:

1. patients with history of gastrointestinal diseases or homologous pathogen infection pre-transplant;
2. pregnant or lactating females;
3. expected survival\<1 months;
4. unable to understand the purpose of the study, communicate effectively with investigators and comply with all study procedures;
5. follow up less than 1-month post-WMT;
6. other conditions judged by investigators not suitable for study participation.

Where it's running

• The Second Affiliated Hospital of Nanjing Medical University
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Principal investigator: Faming Zhang, PhD — The Second Hospital of Nanjing Medical University
• Study coordinator: Faming Zhang, PhD
• Email: fzhang@njmu.edu.cn
• Phone: 086-25-58509883

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.