Transcatheter vs. Surgical Repair for Degenerative Mitral Valve Disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an ambispective cohort study that combines prospective and retrospective data to compare long-term outcomes after transcatheter edge-to-edge repair (TEER) versus surgical repair for degenerative mitral regurgitation. Researchers will collect clinical, procedural, and follow-up information, with advanced imaging like cardiac MRI to identify predictors of left ventricular dysfunction and other outcomes. Patient-reported recovery and quality of life will be measured using validated tools. The study aims to refine care for higher surgical-risk patients by identifying which treatment approach offers better durability and recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients older than 60 years who have DMR will be included in the study

Exclusion Criteria:

* Patients with prior history of mitral intervention or surgery will be excluded.
* Patient records flagged "break the glass" or "research opt out" will be excluded.
* Persons with allergy to animal dander or animal-instigated asthma will be excluded.

Where it's running

• Smidt Heart Institute, Cedars Sinai Medical Center
  Los Angeles, California, United States Recruiting

Study contacts

• Study coordinator: Aakriti Gupta, M.D.
• Email: aakriti.gupta@cshs.org
• Phone: 267-442-8776

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.