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Clinical trial No longer in our active list Interventional Ages 6 to 12

Training breathing muscles in childhood cancer survivors

Official title: Understanding the Influence of Diaphragm Structure and Function on the Control of Breathing During Exercise in Childhood Cancer Survivors (2373GCCC)

Run by University of Maryland, Baltimore · NCT06205251 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is testing a breathing muscle training program for childhood cancer survivors to see if it helps them breathe better and exercise more easily.

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Quick facts

Study typeInterventional
Ages6 Years to 12 Years
SexAll
Enrollment13 (estimated)
SponsorUniversity of Maryland, Baltimore
Academic / other
Drugs / interventionschemotherapy, radiation
Locations1 site (Baltimore, Maryland)
Trial IDNCT06205251 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are childhood cancer survivors who have completed their medical treatment at least one year ago.

Probably not a fit

Patients with a history of neuromuscular, cardiac, or pulmonary disease prior to cancer diagnosis may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to evaluate the feasibility of an inspiratory muscle training program designed for childhood cancer survivors. Participants will first undergo pulmonary function and muscle performance tests, followed by treadmill walking trials to assess their breathing regulation during exercise. After a 6-week home training program for their breathing muscles, participants will have follow-up assessments to measure any changes in their respiratory function and exercise capacity. The study includes weekly telehealth support to ensure adherence to the training regimen.

Why it matters

Potential benefit: If successful, this program could improve respiratory function and exercise tolerance in childhood cancer survivors.

How similar studies have gone: While similar approaches have been explored, this specific focus on childhood cancer survivors and inspiratory muscle training is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Completed medical treatment (chemotherapy, chemotherapy/surgery, chemotherapy/radiation or any combination of cancer treatment) for any type of cancer, except for cancer of the central nervous system, at least 1 year ago

Exclusion Criteria:

* History of neuromuscular, cardiac, or pulmonary disease prior to the diagnosis of cancer
* Recent injury or condition (less than 6 months ago) that precludes strength testing or walking
* Dyspnea with minimal activity (4 on the modified Medical Research Council Dyspnea Scale)

Where it's running

  • University of Maryland, Baltimore
    Baltimore, Maryland, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Childhood Cancer 92Cancer Survivors 282University of Maryland Baltimore 905
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.