Tracking short-term changes in blood metabolites using finger-prick sampling
Monitoring Changes in Blood Circulating Metabolites Using Minimally Invasive Techniques
This project will try daily finger-prick microsampling and wearables to see how blood metabolites and glucose change over four weeks in healthy adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 35 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Örebro University, Sweden Academic / other |
| Locations | 1 site (Örebro) |
| Trial ID | NCT07527793 on ClinicalTrials.gov |
What this trial studies
Healthy adults (18–65 years, BMI 18.5–29.9) will be followed for four weeks with daily finger-prick blood microsamples, routine glucose monitoring, dietary records, and wearable activity/sleep trackers. Mass spectrometry-based metabolomics and lipidomics, including isotope-labelled standards, will be used to profile circulating metabolites and capture pre- and postprandial transitions during habitual meals. No dietary or lifestyle interventions are imposed; data are collected under real-life conditions to measure intra- and inter-individual variability. The study also tests the feasibility and robustness of minimally invasive sampling and wearable-derived physiological data for future larger longitudinal studies.
Who should consider this trial
Good fit: Healthy adults aged 18–65 with BMI 18.5–29.9, stable weight, non-smokers, not taking routine medications or supplements that interfere with metabolism, and willing to perform daily finger-pricks and wear monitoring devices are ideal.
Not a fit: People with chronic diseases, recent antibiotic use, active efforts to lose weight, smokers, those on regular medications, or individuals outside the specified age or BMI ranges are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this could enable easier, lower-cost metabolic monitoring in daily life and support more personalized nutrition or health tracking without venous blood draws.
How similar studies have performed: Similar pilot work combining microsampling, metabolomics, and wearables has shown promise in capturing postprandial metabolic changes, but broader real-life validations remain limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age: 18-65 years old 2. Body Mass Index (BMI): 18.5-29.9 kg/m2 3. Weight stability within the previous 3 months (self-reported). 4. Positive intention to maintain usual routine physical activity and eating habits during the study. Exclusion Criteria: 1. Presence of acute chronic diseases, inflammatory or functional gastrointestinal disorders, or any diagnosed disease condition that disrupt daily routine activities. 2. Routine use medications or supplements that could potentially interfere with the study outcomes 3. History of eating disorder 4. Recent use of antibiotic medication within the last 3 months prior to the first visit 5. Active efforts to lose weight 6. Smoking 7. Consumption of alcoholic drinks exceeding nine standard cups per week and/or more than three standard cups per occasion
Where this trial is running
Örebro
- School of Medical Sciences — Örebro, Sweden (Recruiting)
Study contacts
- Principal investigator: Matej Oresic, Ph.D. — School of Medical Sciences, Orebro University
- Study coordinator: Anh Hoang Nguyen, Ph.D.
- Email: anh-hoang.nguyen@oru.se
- Phone: +46723747116
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.