Total underwater colonoscopy for better colorectal cancer screening
Total Underwater Colonoscopy (TUC) for Improved Colorectal Cancer Screening: A Randomized Controlled Trial
This study is testing if total underwater colonoscopy can find more hard-to-detect lesions during colorectal cancer screening in people who need a colonoscopy after a positive stool test.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 1070 (estimated) |
| Ages | 55 Years to 60 Years |
| Sex | All |
| Sponsor | Vestre Viken Hospital Trust Academic / other |
| Locations | 5 sites (Drammen and 4 other locations) |
| Trial ID | NCT06333392 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of total underwater colonoscopy compared to conventional colonoscopy for colorectal cancer screening. It focuses on improving the detection rates of serrated lesions, which are often missed during standard procedures. Participants will be individuals referred for colonoscopy after a positive fecal immunochemical test (FIT). The study aims to determine if the underwater technique can enhance the identification and resection of these lesions, potentially reducing the risk of colorectal cancer.
Who should consider this trial
Good fit: Ideal candidates are individuals referred for colonoscopy following a positive FIT screening.
Not a fit: Patients with a colorectal cancer diagnosis within the last 10 years will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to earlier detection and treatment of colorectal cancer, improving patient outcomes.
How similar studies have performed: Previous studies have shown promising results with similar underwater colonoscopy techniques, indicating potential for improved outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All individuals referred to colonoscopy after a positive FIT screening at the participating screening centres Exclusion Criteria: * Individuals with a CRC diagnosis within the last 10 years.
Where this trial is running
Drammen and 4 other locations
- Vestre Viken Health Trust, Bærum Hospital — Drammen, Norway (Recruiting)
- Østfold Hospital Health Trust — Grålum, Norway (Recruiting)
- Akershus University Hospital Health Trust — Lørenskog, Norway (Recruiting)
- Ullevål University Hospital Health Trust — Oslo, Norway (Recruiting)
- Sahlgrenska University Hospital, Gothenburg, Region Västra Götaland, Sweden, Department of Medicine, Geriatrics and Emergency Care Mölndal — Gothenburg, Sweden (Not_yet_recruiting)
Study contacts
- Study coordinator: Anna Lisa Schult, MD, PhD
- Email: anschu@vestreviken.no
- Phone: +47 67 80 94 00
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.