Total underwater colonoscopy for better colorectal cancer screening
Official title: Total Underwater Colonoscopy (TUC) for Improved Colorectal Cancer Screening: A Randomized Controlled Trial
Run by Vestre Viken Hospital Trust · NCT06333392 · Data updated 2026-11-12
This study is testing if total underwater colonoscopy can find more hard-to-detect lesions during colorectal cancer screening in people who need a colonoscopy after a positive stool test.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 55 Years to 60 Years |
| Sex | All |
| Enrollment | 1070 (estimated) |
| Sponsor | Vestre Viken Hospital Trust Academic / other |
| Locations | 5 sites (Drammen and 4 other locations) |
| Status | Recruiting |
| Started | October 23, 2024 |
| Main results expected | December 2026 |
| Study ends | June 2027 |
| Registry record updated | September 4, 2026 |
| Trial ID | NCT06333392 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals referred for colonoscopy following a positive FIT screening.
✕Probably not a fit
Patients with a colorectal cancer diagnosis within the last 10 years will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effectiveness of total underwater colonoscopy compared to conventional colonoscopy for colorectal cancer screening. It focuses on improving the detection rates of serrated lesions, which are often missed during standard procedures. Participants will be individuals referred for colonoscopy after a positive fecal immunochemical test (FIT). The study aims to determine if the underwater technique can enhance the identification and resection of these lesions, potentially reducing the risk of colorectal cancer.
Why it matters
Potential benefit: If successful, this approach could lead to earlier detection and treatment of colorectal cancer, improving patient outcomes.
How similar studies have gone: Previous studies have shown promising results with similar underwater colonoscopy techniques, indicating potential for improved outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All individuals referred to colonoscopy after a positive FIT screening at the participating screening centres Exclusion Criteria: * Individuals with a CRC diagnosis within the last 10 years.
Where it's running
-
Vestre Viken Health Trust, Bærum Hospital
Drammen, Norway Recruiting -
Østfold Hospital Health Trust
Grålum, Norway Recruiting -
Akershus University Hospital Health Trust
Lørenskog, Norway Recruiting -
Ullevål University Hospital Health Trust
Oslo, Norway Recruiting -
Sahlgrenska University Hospital, Gothenburg, Region Västra Götaland, Sweden, Department of Medicine, Geriatrics and Emergency Care Mölndal
Gothenburg, Sweden Recruiting
Study contacts
- Study coordinator: Anna Lisa Schult, MD, PhD
- Email: anschu@vestreviken.no
- Phone: +47 67 80 94 00
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.