Total Intravenous Versus Inhalational Anesthesia in Hip Fracture Surgery
Official title: Effect of Total Intravenous Anesthesia Versus Inhalational Anesthesia on Postoperative Quality of Recovery and Cognitive Outcomes in Patients Undergoing Hip Fracture Surgery
Run by Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital · NCT07860996 · Data updated 2026-11-12
This study compares TIVA with sevoflurane anesthesia in people 65 and older undergoing hip fracture surgery to see which method helps them recover better after surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 65 Years and up |
| Sex | All |
| Enrollment | 110 (estimated) |
| Sponsor | Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital Academic / other |
| Locations | 1 site (Istanbul, Istanbul) |
| Status | Recruiting |
| Started | September 30, 2026 |
| Main results expected | March 30, 2027 |
| Study ends | March 30, 2027 |
| Registry record updated | October 13, 2026 |
| Trial ID | NCT07860996 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Patients aged 65 or older undergoing hip fracture surgery under general anesthesia, with ASA I–III, and able to consent or have a representative.
✕Probably not a fit
Patients with ASA IV–V, severe pre-existing cognitive impairment preventing communication, or inability to complete QoR-40 or Turkish language requirements may not benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, single-center observational study enrolling patients 65 years and older undergoing hip fracture surgery under general anesthesia. The anesthetic technique (TIVA with propofol or sevoflurane-based inhalational anesthesia) is chosen by routine clinical practice, not by researchers. The study collects preoperative and intraoperative data, then assesses recovery quality, delirium, cognitive function, pain, opioids, recovery room stay, complications, and satisfaction on postoperative days 1 and 2, with cognitive testing performed by blinded assessors. Outcomes include QoR-40 scores, NRS pain, delirium incidence, opioid consumption, PACU stay, complications, and overall patient satisfaction. Statistical analyses will compare outcomes between the two anesthesia approaches while accounting for baseline characteristics.
Why it matters
Potential benefit: If one technique shows superior recovery or cognitive outcomes, it could inform anesthesia choices for older hip fracture patients to improve postoperative recovery.
How similar studies have gone: Previous observational work in anesthesia approaches has suggested differences in recovery quality, but results in this exact context are limited and this study adds real-world data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 65 years or older * ASA physical status I-III * Scheduled to undergo elective or emergency hip fracture surgery under general anesthesia * Provision of informed consent by the patient and/or legal representative Exclusion Criteria: * Refusal to participate in the study * ASA physical status IV-V * Severe pre-existing neurological or psychiatric disorders, including advanced dementia or severe cognitive impairment preventing communication * Known hypersensitivity or allergy to propofol or sevoflurane * History of chronic heavy opioid or sedative substance use * Inability to communicate in Turkish or to understand and complete the QoR-40 questionnaire
Where it's running
-
Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital
Istanbul, Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Şule Altuncu Altuncu, MD
- Email: sule.621@hotmail.com
- Phone: +90 216 606 33 00
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.