Total intravenous (TIVA) versus sevoflurane inhaled anesthesia during colorectal cancer surgery: effects on muscle mass
Total Intravenous Anesthesia Versus Balanced Anesthesia on Loss of Muscle Mass After Colorectal Cancer Surgery
This will see if total intravenous (TIVA) anesthesia or sevoflurane inhaled anesthesia better preserves muscle mass and strength around the time of open colorectal cancer surgery in adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Grigore T. Popa University of Medicine and Pharmacy Academic / other |
| Locations | 1 site (Iași) |
| Trial ID | NCT07237438 on ClinicalTrials.gov |
What this trial studies
Adults scheduled for open colorectal cancer surgery at the Regional Institute of Oncology in Iași will receive either TIVA or sevoflurane anesthesia during their operation. Muscle mass and function will be measured before and after surgery using ultrasound, handgrip dynamometry, and bioimpedance to track perioperative changes. Investigators will compare the two anesthesia approaches and analyze patient-level risk factors for skeletal muscle loss. The trial excludes patients with neuromuscular disease, limb amputation, paraplegia, or terminal cancer and is conducted at a single center in Romania.
Who should consider this trial
Good fit: Adult patients diagnosed with colorectal cancer and scheduled for open colorectal surgery at the Regional Institute of Oncology, Iași, who can provide consent and do not have major neuromuscular disease or limb amputation are the intended participants.
Not a fit: Patients with terminal cancer, pre-existing neuromuscular disorders, limb amputation, paraplegia, or those unable to consent are excluded and therefore would not receive direct benefit from this intervention.
Why it matters
Potential benefit: If successful, the findings could guide anesthesia choice to reduce perioperative muscle loss and improve postoperative recovery for colorectal cancer patients.
How similar studies have performed: Previous research has linked anesthesia technique to some postoperative outcomes, but direct comparisons of TIVA versus sevoflurane for preserving perioperative muscle mass are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • adult patients diagnosed with colorectal cancer and scheduled for open colorectal surgery at the Regional Institute of Oncology, Iaşi, Romania Exclusion Criteria: * lack the capacity to consent * extremity amputation * paraplegia * diseases affecting the muscles (such as stroke, lower-limb immobilization from a plaster, neurodegenerative diseases, peripheral neuropathy or muscle dystrophy) * terminal cancer
Where this trial is running
Iași
- Regional Institute of Oncology, Iaşi, Romania — Iași, Romania (Recruiting)
Study contacts
- Study coordinator: Ianis Siriopol
- Email: ianis.siriopol@gmail.com
- Phone: +40 746215 967
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.