Topical insulin or hyaluronic acid added to standard cleaning for stage III periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, double-blind trial compares three groups of patients with stage III periodontitis: SRP alone, SRP with topical insulin, and SRP with topical hyaluronic acid. Researchers will measure changes in pocket depth and attachment loss, along with biochemical analyses, to see if the topical treatments offer additional benefit over SRP alone. The study uses computer-based randomization to assign participants and follows a controlled, non-surgical periodontal therapy approach. Eligible participants are adults without systemic illnesses and with good treatment compliance. Outcomes will focus on clinical periodontal improvements and safety signals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All selected patients are free from systemic illness as evaluated according to dental modification of the Cornell medical index.
* Should be diagnosed as having periodontitis.
* Not received any type of periodontal treatment in the past 6 months prior to examination.
* Should be cooperative, motivated, and willing to follow our treatment protocol and follow up visits.
* Not received antibiotics or anti-inflammatory therapy in the 6 months prior to examination.

Exclusion Criteria:

* Antibiotic therapy in the preceding 6 months or during study participation.
* History of insulin dependent diabetes and thyroid disease.
* Pregnancy, smoking, chronic diseases such as diabetes mellitus or rheumatoid arthritis, and allergy to ingredients in the drug.
* Poor oral hygiene compliance or inability to adhere to the clinical protocol.

Where it's running

• Alazhar university
  Cairo, Egypt Recruiting
• Faculty of Dental Medicine for Girls, Al-Azhar University
  Cairo, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.