Tissue adhesive vs sutures for closing oral biopsy wounds

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized trial, adults with oral fibromas undergo excisional biopsy and are assigned to close the wound with either PeriAcryl 90 HV tissue adhesive or nylon 4-0 sutures. The primary goal is to compare wound closure performance between the adhesive and sutures in the oral cavity, including ease of use and healing outcomes. The study aims to determine if the adhesive offers a practical alternative that may reduce procedural time and avoid suture removal. 28 participants (14 per group) are planned, with assessments of healing and complications following closure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

-Patients clinically diagnosed with oral fibroma located on the

labial mucosa (lip) or buccal mucosa (cheek).

* Lesion requires excisional biopsy.
* Lesion size greater than 3 mm and less than 3 cm in

greatest diameter.

Exclusion Criteria:

* Pregnant or breastfeeding women.
* Patients taking anticoagulant medications (blood thinners).
* Patients with infectious diseases such as hepatitis, HIV, etc.
* Patients taking immunosuppressants.
* Patients with uncontrolled diabetes mellitus.
* Patients taking medications that affect bleeding and wound healing.

Where it's running

• Damascus University ,Department of Oral Medicine, Faculty of Dentistry
  Damascus, Mazzh, Syria Recruiting

Study contacts

• Study coordinator: Nour J Ibrahim, DDS _ MSc student
• Email: nouribrahim649@gmail.com
• Phone: +963959800513

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.