Screening for early detection of oral cancer and related disorders
Screening for Oral Cancer for Early Detection of Premalignant Disorders
This study is testing a new, easy way to check for early signs of oral cancer in high-risk people, like tobacco and heavy alcohol users, to help catch it sooner and improve survival rates.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Dalarna County Council, Sweden Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Falun, Dalarna County) |
| Trial ID | NCT05296941 on ClinicalTrials.gov |
What this trial studies
This study aims to develop a cost-effective system for the continuous monitoring of mucosal lesions in the oral cavity using non-invasive brush biopsy techniques. By focusing on high-risk individuals, such as tobacco users and those with excessive alcohol consumption, the study seeks to implement early diagnostic screening to improve survival rates for oral cancer. The approach is designed to be manageable within primary dental care settings, potentially reducing the reliance on more invasive tissue biopsies. The ultimate goal is to decrease the incidence of late-stage oral cancers, which have significantly poorer prognoses.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 18 and older with a clinical diagnosis of leukoplakia, erythroplakia, or proliferative verrucous leukoplakia.
Not a fit: Patients currently undergoing chemotherapy or radiotherapy, or those unable to understand information in Swedish, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection of oral cancers, improving survival rates and quality of life for patients.
How similar studies have performed: Other studies have shown promise in using non-invasive techniques for early cancer detection, suggesting that this approach could be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • Persons 18 years of age or older who have the clinical diagnosis of leukoplakia, erythroplakia or proliferative verrukös leukoplakia Exclusion Criteria: * People who cannot read and understand information in Swedish. * Ongoing chemotherapy and/or radiotherapy.
Where this trial is running
Falun, Dalarna County
- Kristina Edman — Falun, Dalarna County, Sweden (Recruiting)
Study contacts
- Principal investigator: Public dental care — Uppsala University
- Study coordinator: Kristina Edman, PhD
- Email: kristina.edman@regiondalarna.se
- Phone: +46(0)70 5349476
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.