Dezocine versus nalbuphine with sufentanil for pain control after oral cancer surgery with free-flap reconstruction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, prospective, randomized, double-blind trial will enroll 60 adult patients undergoing radical oral cancer surgery with free flap reconstruction and randomize them 1:1 to postoperative PCIA with sufentanil plus either dezocine or nalbuphine. Both groups receive identical PCIA settings and a standardized general anesthesia protocol. The primary outcome is resting VAS pain at 2, 24, and 48 hours after surgery, with secondary outcomes including flap survival and complications, flap sensory function, common opioid-related adverse events, sedation scores, and length of hospital stay. Investigators will also record intraoperative hemodynamics and blood loss to explore differences between groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Diagnosed with oral malignant tumor.
2. Scheduled for oral cancer radical surgery with free flap reconstruction at Sun Yat-sen Memorial Hospital.
3. Age between 18 and 70 years.
4. Sign informed consent.

Exclusion Criteria:

1. Use of analgesic medications within two weeks prior to surgery.
2. History of diabetes, arteriosclerosis, or peripheral vascular disease.
3. Use of hormones, chemotherapy, or immunosuppressants.
4. Severe cardiac, pulmonary, hematological, hepatic, or renal diseases.
5. Known allergy to the study drugs.

Where it's running

• Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen Universit
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: Ganglan Fu, M.D.
• Email: ganglan@126.com
• Phone: 86+13570275074

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.