Clinical trial Recruiting at 1 site Observational Ages 18 to 99

TIPS treatment for decompensated liver cirrhosis

Official title: Benefits and Limitations of Transjugular Intrahepatic Portosystemic Shunts (TIPS) in Patients With Decompensated Liver Cirrhosis

Run by Hannover Medical School · NCT04801290 · Data updated 2026-11-12

Collecting clinical data and blood samples from adults with decompensated liver cirrhosis who receive a TIPS to try to improve how doctors choose who should get the procedure.

Quick facts

Study typeObservational
Ages18 Years to 99 Years
SexAll
Enrollment250 (estimated)
SponsorHannover Medical School
Academic / other
Locations1 site (Hanover, Lower Saxony)
StatusRecruiting
StartedAugust 29, 2019
Main results expectedDecember 2027
Study endsDecember 2027
Registry record updatedSeptember 16, 2025
Trial IDNCT04801290 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (age 18+) with liver cirrhosis who have an indication for TIPS and are treated at Hannover Medical School who can give informed consent.

Probably not a fit

People under 18, pregnant or breastfeeding patients, those with symptomatic severe anemia (hemoglobin <7 g/dL), or patients treated elsewhere will not qualify and are less likely to benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center registry at Hannover Medical School enrolls patients with liver cirrhosis who undergo transjugular intrahepatic portosystemic shunt (TIPS) as part of routine care. Clinical data, laboratory results and blood samples are collected prospectively to identify factors linked to outcomes such as control of ascites, prevention of variceal bleeding, hepatic encephalopathy, and survival. No experimental treatments are given; TIPS is performed according to standard clinical practice and patients are followed over time. The aim is to refine selection criteria and management strategies to reduce complications and improve outcomes for future patients.

Why it matters

Potential benefit: If successful, this work could help doctors select patients who will benefit most from TIPS and reduce procedure-related complications.

How similar studies have gone: TIPS is an established treatment for portal hypertension complications like refractory ascites and variceal bleeding, and prior multicenter studies have shown benefit, while registries are commonly used to refine patient selection.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Liver cirrhosis
* Indication for TIPS insertion
* Treatment at the Department of Gastroenterology, Hepatology and Endocrinology of Hannover Medical School
* Informed consent

Exclusion Criteria:

* Pregnancy or Lactation
* Age \<18 years
* Lack of Informed consent
* Symptomatic anemia with Hb \<7g/dl

Where it's running

  • Hannover Medical School
    Hanover, Lower Saxony, Germany
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Single vs repeated cycles of G-CSF and darbepoetin in early decompensated cirrhosis

    This trial tests whether giving multiple rounds of G-CSF plus darbepoetin helps people with early decompensated cirrhosis more than a single round or standard care.

    Recruiting Institute of Liver and Biliary Sciences, India · New Delhi, National Capital Territory of Delhi · NCT07002827

  • Atorvastatin plus beta-blockers for people with decompensated cirrhosis

    This pilot Phase 2 trial will test whether adding atorvastatin 20 mg to standard non‑selective beta‑blocker therapy helps adults with decompensated cirrhosis avoid complications over 12 months.

    Recruiting Phase 2 CAMC Health System · Charleston, West Virginia · NCT06764966

  • LEOPARD: Predicting liver transplant dropout with AI in European patients

    This project tests new AI-based models to predict which liver transplant candidates are at highest risk of dropout or death while on the waitlist.

    Recruiting at 4 sites Assistance Publique - Hôpitaux de Paris · Ghent, Belgium and 7 other locations · NCT06723275

  • Collecting data to improve liver transplantation predictions

    This study is trying to use AI to better predict which liver transplant candidates are at risk of dropping out of the waitlist, so that more people can get fair access to transplants across Europe.

    Recruiting at 53 sites Assistance Publique - Hôpitaux de Paris · Vienna and 52 other locations · NCT06675604

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.