Timing broccoli sprout intake to see if it boosts endurance performance

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized, double-blind, placebo-controlled crossover trial, healthy endurance athletes will complete four visits at the Swedish School of Sport and Health Sciences. Participants receive either an active broccoli sprout drink or a placebo made from alfalfa sprouts, with timing varied to examine subacute (about 16 hours before) versus acute (about 3 hours before) intake relative to a standardized 2-hour cycling protocol. The study uses indirect calorimetry for VO2 measurements and blood lactate and glucose sampling to assess physiological responses and recovery. The primary aim is to isolate the effect of ITC timing from broccoli sprouts on performance and post-exercise metabolism.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Healthy, endurance-trained adults aged 18-64 years.

Regular endurance training (e.g., cycling/running) and ability to complete a standardized 2-hour high-intensity cycling session on an ergometer.

Approved health declaration and screening assessment by study staff (including that ergometer testing can be performed safely).

Willing and able to follow the study protocol (diet/fasting instructions, standardized training before visits, attendance at all four laboratory visits).

No known allergy/hypersensitivity to ingredients in the broccoli sprout drink or placebo drink.

Exclusion Criteria:

Does not meet inclusion criteria at screening (e.g., abnormal health declaration or medical findings making intense endurance exercise or muscle biopsy inappropriate).

Known allergy/hypersensitivity to ingredients in the intervention or placebo drink (broccoli/cruciferous vegetables or alfalfa) or other relevant food allergy.

Ongoing illness, fever, or infection at any test occasion, or other acute medical event judged to affect safety or data quality.

Ongoing treatment with medications/supplements judged to affect primary outcomes or increase risk (e.g., anti-inflammatory medication close to test days per study instructions).

Pregnancy (if women are included) or breastfeeding.

Inability to comply with the study protocol (e.g., failure to standardize diet/fasting, deviating training/alcohol intake despite instructions, or repeated missed visits).

Participant withdraws consent or investigator judges continued participation to pose risk.

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Where it's running

• Swedish School of Sport and Health Sciences
  Stockholm, Stockholm County, Sweden Recruiting

Study contacts

• Study coordinator: Filip J Larsen, PhD
• Email: filip.larsen@gih.se
• Phone: 08-120 53 700

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.