Therapy to improve wellbeing in young brain tumor survivors

Acceptance and Commitment Therapy for Young Brain Tumour Survivors: An Acceptability and Feasibility Trial

Not applicable Interventional Nottingham University Hospitals NHS Trust · NCT04722237

This study is testing whether a new online therapy can help young brain tumor survivors aged 11-24 feel better and improve their quality of life after treatment.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment72 (estimated)
Ages11 Years to 24 Years
SexAll
SponsorNottingham University Hospitals NHS Trust Academic / other
Locations1 site (Nottingham)
Trial IDNCT04722237 on ClinicalTrials.gov

What this trial studies

This study evaluates the feasibility and acceptability of remotely delivered Acceptance and Commitment Therapy (ACT) for improving the quality of life in young survivors of brain tumors aged 11-24 years. Participants will be randomly assigned to receive 12 weeks of ACT immediately or after a 12-week wait, with follow-up assessments conducted at 24, 36, and 48 weeks to measure the durability of treatment effects. The study aims to address the significant physical and psychological challenges faced by this population after completing cancer treatment.

Who should consider this trial

Good fit: Ideal candidates are young individuals aged 11-24 who have completed treatment for a brain tumor and have stable health for at least six months.

Not a fit: Patients currently undergoing treatment for brain tumors or those with severe psychological conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this therapy could significantly enhance the quality of life for young brain tumor survivors.

How similar studies have performed: Other studies have shown promise in using psychological interventions like ACT for improving quality of life in cancer survivors, suggesting a potential for success in this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Aged 11-to-24 years at the time of randomisation
* Received treatment for a brain tumour at a participating Principle Treatment Centre
* Active brain tumour treatment is complete and their condition stable for at least six-months
* Have sufficient cognitive ability to engage with ACT sessions as judged by the clinician at baseline assessment
* competent to provide informed consent (participants aged 16 or over) or assent (participants aged 11-15)
* Parent/carer competent to provide informed consent (for participants aged 11-15)

Exclusion Criteria:

* Received a structured behavioural intervention within six-months prior to study recruitment
* Previous or current alcohol/substance dependence, psychosis, suicidality, or eating disorder
* Moderate or severe intellectual disability, confirmed through researcher judgement at screening through questions relating to school type and previous diagnoses
* Immediate risk to self or others
* The patient or their parent/carer is not able to speak, read or write English

Where this trial is running

Nottingham

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Brain TumorsQuality of LifeBrain Tumor, PediatricAcceptance and Commitment TherapyCancerOncologyQuality of survivalchildren and adolescents
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.