Testing for viruses after a monkey bite
Virus Transmission to People Recently Bitten or With a History of Monkey Bites "SIMVIR"
We will test adults who were recently bitten by a monkey or who have a history of monkey bites to see if they carry simian viruses such as STLV-1 or SFV using blood and saliva samples.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Institut Pasteur Industry-sponsored |
| Locations | 1 site (Paris) |
| Trial ID | NCT07097480 on ClinicalTrials.gov |
What this trial studies
This interventional study enrolls adults (≥18) who sustained WHO category 3 bites from nonhuman primates, including both recent and past exposures. Participants provide blood and saliva samples, with an optional genetic analysis component for those who consent. Samples will be tested for simian viruses (STLV-1 and SFV) to estimate prevalence and characterize possible transmission after bites. Enrollment and sample processing are conducted at the Institut Pasteur Medical Center in Paris.
Who should consider this trial
Good fit: Adults (age ≥18) who experienced a WHO category 3 bite from a nonhuman primate, can give written informed consent, and are affiliated with a French social security scheme are ideal candidates.
Not a fit: People who only had scratches from nonhuman primates, minors, those under legal protection, or those whose medical care prevents sample collection are unlikely to benefit from joining.
Why it matters
Potential benefit: If successful, the study could help identify people who carry simian viruses after monkey bites and improve post-bite monitoring and prevention recommendations.
How similar studies have performed: Field and occupational studies have documented human SFV infections and occasional STLV-1 related findings after primate exposure, but systematic post-bite prevalence studies are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Bite inflicted by an HNP (WHO category 3 level) * Written informed consent * Affiliation with a social security scheme (excluding State Medical Aid Specific criteria for genetic analyses: * Participant has checked the boxes for participation in the genetic component. Exclusion Criteria: * Patient presenting only with scratches inflicted by a PNH * Medical management incompatible with the objectives of the study * Patient who, in the doctor's opinion, is unlikely to comply with the study protocol * Health conditions are incompatible with the sample collection required by the study * Patient under legal protection (guardianship or trusteeship)
Where this trial is running
Paris
- Institut Pasteur Medical Center — Paris, France (Recruiting)
Study contacts
- Principal investigator: Patrick HOCHEDEZ, Dr — Institut Pasteur Medical Center
- Study coordinator: Florence BUSEYNE, PhD
- Email: florence.buseyne@pasteur.fr
- Phone: 0145688899
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.