Exploring immune responses to yellow fever vaccination

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the immune response generated by yellow fever and typhoid vaccinations, focusing on the concept of innate immune memory or 'trained immunity'. It aims to determine whether live attenuated vaccines can provide non-specific protection against various infections beyond their intended targets. Participants will have blood samples collected to analyze their immune responses following vaccination. The study is conducted in a real-world setting to observe the effects of these vaccines on the immune system.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18 and 65
* Referred for immunisation against yellow fever and typhoid
* Any person with indication for the following vaccinations :
* Yellow fever
* Typhoïd
* Whose vaccination schedule includes two appointments 7 days apart
* Whose state of health is compatible with a single 51 ml blood sample collection
* Have consented to participate in the Ivory2 study
* Benefiting from a Social Security plan or equivalent

Exclusion Criteria:

* Anyone with a contraindication to yellow fever and/or typhoid vaccination.
* Any person who has been vaccinated against yellow fever and/or typhoid.
* Anyone who has lived in an endemic area (≥ 1 year) and/or has a history of Typhoid.
* Anyone who is unable to attend the visit 1-month after the typhoid vaccine injection.
* Women claiming to be pregnant or breast-feeding
* Anyone unable to give informed consent for participation

Where it's running

• Centre Médical de l'Institut Pasteur
  Paris, France Recruiting

Study contacts

• Principal investigator: Fabien Taieb, Dr — Institut Pasteur
• Study coordinator: Jessica Quintin, Dr
• Email: jessica.quintin@pasteur.fr
• Phone: 144389454

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.