Comparing yellow fever vaccination effects during and outside of pregnancy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the immunogenicity and tolerance of the yellow fever vaccine when administered to pregnant women compared to those vaccinated outside of pregnancy. It involves collecting blood samples to assess the immune response and any potential adverse effects on both the mother and fetus. Given the risks associated with yellow fever, especially in endemic regions, understanding the safety and efficacy of vaccination during pregnancy is crucial for public health. The study is conducted at the Institut Pasteur in Paris, focusing on women who meet specific eligibility criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Common :

* Person over 18 years of age at the time of the first yellow fever vaccination
* Female gender
* Oral consent obtained after subject has been informed
* Subject covered by Social Security with the exception of Aide Médicale d'Etat

Specific to both groups :

* For women vaccinated during pregnancy (case): Primary yellow fever vaccination during pregnancy
* For women vaccinated outside pregnancy (control): Primary yellow fever vaccination outside pregnancy

Exclusion Criteria:

Criteria common to both sections (tolerance and immunogenicity):

* Subject having received a second yellow fever vaccination
* Persons unable to give informed consent for participation
* Women born in areas where yellow fever is endemic
* Female adults under legal protection (guardianship or trusteeship)

Specific criteria for participants in the immunogenicity section:

* Medical condition imcompatible with 18.5 mL blood
* Women who have not given written consent to participate in the study. immunogenicity

Where it's running

• Medical Center of Institut Pasteur
  Paris, France Recruiting

Study contacts

• Principal investigator: Kaoutar JIDAR, MD — Medical Center of l'Institut Pasteur (CMIP)
• Study coordinator: Kaoutar JIDAR, MD
• Email: kaoutar.jidar@pasteur.fr
• Phone: 0140613817

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.