tDCS to reduce itching after cesarean with epidural morphine

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study focuses on cesarean patients who receive epidural morphine for pain control. It tests whether applying a safe, noninvasive brain stimulation, tDCS, can modulate neural pathways involved in itch to lower the risk of opioid-induced pruritus. Participants will receive either real tDCS or placebo stimulation as part of the protocol. The trial targets adult women with full-term, singleton pregnancies scheduled for cesarean delivery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-40 years, gestational age 37-41 weeks, singleton full-term pregnancy;
* Planned elective or emergency cesarean section, using epidural anesthesia (0.1\~0.2 mg/kg of morphine administered intrathecally during surgery);
* American Society of Anesthesiologists (ASA) classification I-III;
* Conscious and able to cooperate to complete scale assessments, serum sample collection, and postoperative follow-up;
* Voluntarily participate in the study and sign the informed consent form.

Exclusion Criteria:

* Presence of contraindications for tDCS (such as skull defects, intracranial metal implants, history of epilepsy, coagulation disorders);
* Allergy to opioids or a history of severe OEI;
* Presence of skin diseases (such as eczema, urticaria), liver diseases (cholestasis), mental disorders, or cognitive impairments;
* Coexisting pregnancy complications (preeclampsia, gestational diabetes, autoimmune diseases);
* Use of medications within the past week that may affect itch assessment, such as antihistamines, 5-HT3 receptor antagonists, or anti-inflammatory drugs.

Where it's running

• Affiliated hospital of Nantong University
  Nantong, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Chao Chao Zhong, M.D.
• Email: zhong249767626@163.com
• Phone: 15152460489

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.