Tailored physical activity program for metastatic breast cancer patients

A Tailored Physical Activity Program to Address Physical Inactivity Amongst Metastatic Breast Cancer Patients

Not applicable Interventional Thomas Jefferson University · NCT06500858

This study tests a personalized exercise program for people with metastatic breast cancer to see if it can improve their quality of life and physical health.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment50 (estimated)
Ages18 Years to 120 Years
SexFemale
SponsorThomas Jefferson University Academic / other
Locations1 site (Philadelphia, Pennsylvania)
Trial IDNCT06500858 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the effects of a personalized physical activity program on patients with metastatic breast cancer. The program is designed by a qualified cancer exercise specialist and includes a comprehensive assessment to tailor exercise interventions to individual needs. It aims to address the decline in physical activity that can negatively impact quality of life and physical functioning in these patients. Participants will engage in a home-based exercise regimen, along with health promotion and education, to enhance their overall well-being.

Who should consider this trial

Good fit: Ideal candidates are females aged 18 and older diagnosed with metastatic breast cancer who are insufficiently active and have a performance status of ECOG 0-2.

Not a fit: Patients with severe or unstable cardiopulmonary, metabolic, or renal diseases may not benefit from this study.

Why it matters

Potential benefit: If successful, this program could significantly improve physical fitness, quality of life, and reduce cancer-related fatigue in patients with metastatic breast cancer.

How similar studies have performed: Other studies have shown positive outcomes with exercise interventions in cancer patients, suggesting that this approach may be beneficial.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Female
* Aged 18 and older
* Able to read and speak English
* Diagnosed with metastatic breast cancer within 60 months of study enrollment
* Performance status Eastern Cooperative Oncology Group (ECOG) 0-2
* Insufficiently inactive defined as answer "no" to screening question "On average, do you engage in at least 75 minutes a week of vigorous activity (like jogging) or at least 150 minutes a week of moderate activity (like a brisk walk)?"
* Able to comprehend and sign a written informed consent (no cognitive decline)
* Willing to comply with all study procedures and be available for the duration of the study through at least week 2 of 2Unstoppable
* Medically cleared by co-investigator or principal investigator (PI) to engage in aerobic and resistance exercise intervention
* Access to a smart device and have an active wi-fi connection at home

Exclusion Criteria:

* Severe or unstable cardiopulmonary, metabolic, or renal disease
* Unable to walk safely without physical assistance of another person or assistive device
* Any condition that may limit the ability to comply with behavioral and physical recommendations of the virtual exercise program
* Pregnancy

Where this trial is running

Philadelphia, Pennsylvania

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast Carcinoma
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.