Synbiotic capsules for adults on peritoneal dialysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized, double-blind trial, adults on home peritoneal dialysis will receive daily synbiotic capsules or an identical placebo for six months. Researchers will measure inflammatory markers (CRP, ESR), uremic toxins (p-cresol, indoxyl sulfate), and malnutrition-inflammation status, plus track peritonitis episodes. Participants will have visits at baseline, 3 months, and 6 months for blood tests and nutritional assessments. The aim is to determine if synbiotics can improve gut-related biomarkers and clinical outcomes in this patient group.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 18 years or older.
* Patients diagnosed with kidney disease who have been receiving peritoneal dialysis at home for at least 1 month.

Exclusion Criteria:

* Patients who are unable to eat or receive food through a feeding tube.
* Patients who have taken prebiotics or probiotics (supplements that support gut health) in the month before the study starts.
* Patients who used antibiotics in the month before the study starts.
* Patients who cannot attend the scheduled follow-up visits (missing the second follow-up appointment will result in being removed from the study).
* Note on non-adherence and withdrawal: Patients who are unable to take their assigned capsules regularly (taking less than 80% of the total capsules will result in being removed from the study).

Where it's running

• Hospital Universitario Dr. José E. González, Centro Regional de Enfermedades Renales (CRER)
  Monterrey, Nuevo León, Mexico Recruiting

Study contacts

• Principal investigator: Elisa María Guadalupe Guerrero González, MD — Hospital Universitario. Dr. José Eleuterio González
• Study coordinator: Elisa María Guadalupe Guerrero González, MD
• Email: eguerrerog@uanl.edu.mx
• Phone: 528182803788

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.