Sustained thrombectomy plus PCI versus PCI alone in high thrombus burden STEMI
Official title: Comparative Evaluation of Sustained meChanical AsPiration Thrombectomy and no Thrombus Modification for Pre-stent Thrombus bUrden Reduction in Patients With Acute Myocardial Infarction Study: the CAPTURE AMI Study
Run by Oxford University Hospitals NHS Trust · NCT07687576 · Data updated 2026-11-12
This trial tests whether adding sustained mechanical thrombectomy to PCI helps patients with STEMI and large clot burden, compared to PCI alone.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Oxford University Hospitals NHS Trust Academic / other |
| Locations | 1 site (Oxford, Oxfordshire) |
| Status | Recruiting |
| Started | July 8, 2026 |
| Main results expected | July 8, 2027 |
| Study ends | January 8, 2028 |
| Registry record updated | July 10, 2026 |
| Trial ID | NCT07687576 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older with STEMI undergoing primary PCI, high thrombus burden (TIMI ≥4) and culprit vessel diameter ≥3.0 mm.
✕Probably not a fit
Patients without high thrombus burden or with unsuitable anatomy or unstable condition may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
CAPTURE AMI is a randomized, two-arm, investigator-initiated trial conducted at a single center. Adults with STEMI undergoing primary PCI and with high thrombus burden (TIMI thrombus grade ≥4) and culprit vessel diameter ≥3.0 mm are eligible and randomized 1:1 to receive either standalone PCI or sustained mechanical thrombectomy followed by PCI. The primary imaging endpoint is pre-stent thrombus burden percentage, aiming to see if thrombectomy reduces clot load and improves microvascular outcomes. Interventions include sustained thrombectomy and standard PCI, with eligibility criteria designed to select patients at high risk from thrombus-related complications. The study is led by Oxford University Hospitals NHS Trust, conducted at the Oxford Heart Centre.
Why it matters
Potential benefit: If successful, the approach could reduce thrombus burden and potentially improve microvascular flow and outcomes after STEMI.
How similar studies have gone: Previous research in thrombectomy has shown mixed results; this study tests a targeted, sustained technique in a well-defined high-thrombus subgroup.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Primary PCI patient with ST elevation myocardial infarction * Angiographic criteria: * TIMI 0/1 flow at presentation * Angiographic thrombus score ≥ 4 * Vessel diameter at site of occlusion ≥ 3.0mm (determined by coronary angiography) Exclusion Criteria: * Female participant who is pregnant or lactating * Unconscious at presentation * Late STEMI presentation (symptoms onset to wire time \> 12 h) * Clinically/haemodynamically unstable patients * Known diagnosis of severe renal disease (CKD stage 4-5) * Suspected spontaneous coronary artery dissection * Previous CABG * Previous history on STEMI in the same culprit territory * Known moderate-severe anaemia (Hb \< 9)
Where it's running
-
Oxford Heart Centre - John Radcliffe Hospital
Oxford, Oxfordshire, United Kingdom Recruiting
Study contacts
- Study coordinator: Giovanni Luigi De Maria, MD
- Email: GiovanniLuigi.DeMaria@ouh.nhs.uk
- Phone: +44 18655 528364
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.