Clinical trial Recruiting at 1 site Observational Ages 18 and up Women only

Survival in people with poor-prognosis epithelial ovarian cancer

Official title: Survival Analysis in patiEnts With Bad Prognosis Epithelial Ovarian CArcinoma

Run by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT07540403 · Data updated 2026-11-12

We will collect clinical and tumor information to see if people with recurrent epithelial ovarian cancer who have a progression-free survival of 6 months or less have different survival outcomes.

More Ovarian Cancer trials

Quick facts

Study typeObservational
Ages18 Years and up
SexWomen only
Enrollment50 (estimated)
SponsorFondazione Policlinico Universitario Agostino Gemelli IRCCS
Academic / other
Locations1 site (Rome)
StatusRecruiting
StartedMarch 24, 2025
Main results expectedMarch 1, 2027
Study endsMarch 1, 2027
Registry record updatedApril 20, 2026
Trial IDNCT07540403 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (age ≥18) with histologically confirmed epithelial ovarian, fallopian tube, or primary peritoneal carcinoma, a PFS ≤6 months for the recurrent disease, ECOG performance status ≤2, and who provide consent for use of their data.

Probably not a fit

People with non-epithelial ovarian tumors, a PFS >6 months, or who are under 18 are not eligible and would not be expected to benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project will register consecutive adults with histologically confirmed epithelial ovarian, fallopian tube, or primary peritoneal carcinoma who experienced recurrence with a progression-free survival (PFS) of 6 months or less. Investigators will enter anonymized clinical, pathological, and prognostic data into a central database. The dataset will be analyzed to describe survival patterns and to explore clinical or tumor features associated with poorer outcomes. No experimental treatments are given as part of the protocol; the work is a retrospective/prospective registry to refine prognostic categorization.

Why it matters

Potential benefit: If successful, the analysis could help identify subgroups with especially poor prognosis and inform future treatment decisions and trial eligibility criteria.

How similar studies have gone: Previous observational registries and analyses have linked short PFS to poorer outcomes, so this work builds on existing evidence rather than testing a novel therapy.

Who can join: the full rules

Show full inclusion / exclusion criteria
1. INCLUSION CRITERIA

   * Patients diagnosed with histologically confirmed epithelial ovarian carcinoma, fallopian tube carcinoma, or primary peritoneal carcinoma with a PFS ≤6 months.
   * Age ≥18 years.
   * Any FIGO (Federation of Gynecology and Obstetrics) stage at diagnosis.
   * Signed informed consent for the use of personal data for research purposes.
   * ECOG performance status ≤2.
2. EXCLUSION CRITERIA

   * Age \<18 years.
   * Patients with non-epithelial ovarian carcinoma.
   * Patients with a PFS \>6 months.

Where it's running

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS
    Rome, Italy
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • CG-7321: a first-in-human test in advanced solid tumors

    We’re testing CG-7321 alone and with fulvestrant to see if it’s safe and tolerable in adults with advanced solid tumors.

    Recruiting at 4 sites Phase 1 Chengdu Cynogen Bio-pharmaceutical Tech. Co., Ltd. · Fuzhou, Fujian and 3 other locations · NCT07923214

  • CR-002 study in adults with advanced solid tumors

    This trial tests CR-002 as a single therapy to see if it is safe and tolerable in adults with locally advanced or metastatic solid tumors

    Recruiting at 3 sites Phase 1/2 Crescent Biopharma, Inc. · Austin, Texas and 2 other locations · NCT07909031

  • VT-101 in Advanced Ovarian Cancer: early safety study in adults

    This early-phase trial tests VT-101 in adult women with advanced, recurrent, or relapsed epithelial ovarian cancer to see if it is safe, how the body handles it, and whether there are any initial signs of activity.

    Recruiting Phase 1 University of Iowa · Iowa City, Iowa · NCT07905677

  • Methylation markers in self-samples to help detect gynecological cancers

    This study tests whether self-collected urine and vaginal samples can reveal DNA methylation or other genetic markers that indicate endometrial, ovarian, vulvar, or vaginal cancers in women who are at risk or have postmenopausal bleeding.

    Recruiting Universiteit Antwerpen · Edegem, Antwerp · NCT07902375

  • Radiotherapy for gynecologic cancer with up to 10 metastatic sites

    This registry follows adults with gynecologic cancer who have 1 to 10 active metastatic lesions and are treated with radiotherapy as part of routine care to see how such treatments work in real-world settings.

    Recruiting Affidea Nu-med Center of Oncological DIagnostics and Therapy · Zamość · NCT07883798

  • EHR-based approach to boost HBOC genetic testing in at-risk women

    A new EHR tool-based program tests whether computer prompts and real patient resources can help more women with family histories of breast or ovarian cancer get HBOC genetic testing.

    Recruiting Columbia University · New York, New York · NCT07876349

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.