Supervised cycling program to ease chemotherapy-related nerve symptoms
Official title: Evaluating the Acceptability of a Cycling-Based Aerobic Exercise Intervention for Individuals With Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Proof-of-Concept Study
Run by University of Alberta · NCT07150117 · Data updated 2026-11-12
This trial tests if a supervised stationary cycling program can reduce numbness, tingling, and pain in adults with chemotherapy-induced peripheral neuropathy and improve function.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Alberta Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Edmonton, Alberta) |
| Status | Recruiting |
| Started | January 26, 2026 |
| Main results expected | January 31, 2027 |
| Study ends | June 30, 2027 |
| Registry record updated | March 12, 2026 |
| Trial ID | NCT07150117 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with stage I–III cancer who have mild (grade 1) chemotherapy-induced peripheral neuropathy, can read English, are not already in an aerobic training program, and can attend supervised sessions are ideal candidates.
✕Probably not a fit
Patients with other causes of neuropathy (for example diabetes), uncontrolled medical conditions, those undergoing surgery or radiation during the study, or those already doing aerobic training are unlikely to benefit from this program.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a 12-week proof-of-concept intervention in which 30 adults with mild (grade 1) chemotherapy-induced peripheral neuropathy will take part in supervised stationary cycling sessions twice weekly, each lasting 30–60 minutes and progressing over time. The study will track feasibility measures (recruitment, adherence, completion, satisfaction, and safety) alongside patient-reported symptoms and objective functional and fitness outcomes. Both patient-reported outcome measures and objective tests will be used to characterize changes in CIPN symptoms and function. Results will inform whether a larger-scale trial is warranted.
Why it matters
Potential benefit: If successful, the program could reduce CIPN symptoms like pain and numbness and improve physical function and quality of life.
How similar studies have gone: Multimodal exercise programs have shown promising reductions in CIPN symptoms in prior work, but aerobic-only interventions with objective outcome measures remain relatively untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years or older * Cancer diagnosis stage I to III * CIPN: grade 1 (mild) * Receiving or have received chemotherapy treatment for cancer * Speak, read and understand English Exclusion Criteria: * Medical conditions that cause additional neuropathy symptoms (i.e. diabetes) * Any uncontrolled medical conditions * Will undergo surgery or radiation therapy during the study period * Are already receiving an aerobic exercise training program * Are already participating in an exercise-based research study * Are unable to provide signed informed consent
Where it's running
-
Cross Cancer Institute
Edmonton, Alberta, Canada Recruiting
Study contacts
- Principal investigator: Margaret L McNeely, PhD — University of Alberta
- Study coordinator: Christopher Sellar, PhD
- Email: frmace@ualberta.ca
- Phone: 1-780-492-6007
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.