Subtransverse Interligamentary Block vs Paravertebral Block for Quality of Recovery After Mastectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, randomized, double-blinded non-inferiority trial will enroll 60 adult women undergoing unilateral modified radical mastectomy under general anesthesia at Tanta University Hospitals over six months. Participants will receive either the Subtransverse interligamentary (STIL) plane block or a thoracic paravertebral block to manage postoperative pain, with QoR-15 used to measure recovery quality. The study aims to determine if STIL provides recovery outcomes not worse than TPVB while potentially reducingTechnical risks and complexity associated with paravertebral techniques. Outcomes will inform whether STIL is a viable alternative for regional anesthesia in breast surgery. Safety monitoring will capture adverse events and block-related complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult female patients aged 18 to 65 years with American Society of Anesthesiologists (ASA) Physical Status I - III, who were scheduled for unilateral MRM surgery under general anesthesia and able to understand and complete the QoR-15 questionnaire

Exclusion Criteria:

* • Patients declined to participate in the trial.

  * History of allergy to the used local anesthetic (LA) drugs.
  * Patients with cutaneous lesions at the needle entry point.
  * Coagulopathy or current anticoagulant therapy contraindicating regional block.
  * Patients with severe hepatic, renal, cardiac, or respiratory disease.
  * Psychiatric or cognitive disorder interfering with QoR-15 assessment
  * Chronic opioid use or chronic pain syndrome.
  * Failed block.
  * Morbid obesity (body mass index \>40 kg/m2)
  * Intraoperative major complications requiring postoperative ICU admission.
  * Pregnancy

Where it's running

• Tanta university hospital
  Tanta, Gharbia Governorate, Egypt Recruiting
• Tanta university hospital
  Tanta, Egypt Recruiting

Study contacts

• Study coordinator: Mai Salah Salem, MD anesthesia, SIC
• Email: mai.salah@med.tanta.edu.eg
• Phone: 01061107658

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Combined PECS II and PIP blocks vs TPVB for post-mastectomy pain relief

  This trial tests whether a combination of PECS II and superficial PIP blocks can provide better or similar pain relief after mastectomy compared with the standard thoracic paravertebral block.

  Recruiting Dharmais National Cancer Center Hospital · Jakarta, DKI Jakarta · NCT07738770

• Breathwork for older adults after knee replacement

  This study tests whether a quick, at-home breathwork activity can help adults 65 and older recover better after knee replacement surgery.

  Recruiting University of Arizona · Tucson, Arizona · NCT07464860

• Costotransverse foramen block versus erector spinae plane block for pain control in modified radical mastectomy

  This test will see if the costotransverse foramen block or the erector spinae plane block provides better pain relief after modified radical mastectomy in adult women.

  Recruiting National Cancer Institute, Egypt · Cairo · NCT07367568

• Perioperative oxygen comparison for adults having major surgery

  This will test whether giving higher (80%), medium (50%), or lower (≤30%) oxygen during and right after major surgery changes wound infection rates and recovery for adults having longer operations.

  Recruiting at 2 sites Phase 4 Monash University · Melbourne, Victoria and 1 other locations · NCT07186634

• Comparing two types of nerve blocks for pain relief after breast cancer surgery

  This study is testing which of two nerve block techniques helps women have less pain after breast cancer surgery.

  Recruiting Phase 3 Ain Shams University · Cairo, Waili · NCT06947330

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.