Costotransverse foramen block versus erector spinae plane block for pain control in modified radical mastectomy
Comparison of Costotransverse Foramen Block With Erector Spinae Plane Block in Modified Radical Mastectomy: A Randomized Controlled Trial
This test will see if the costotransverse foramen block or the erector spinae plane block provides better pain relief after modified radical mastectomy in adult women.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 110 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | Female |
| Sponsor | National Cancer Institute, Egypt Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT07367568 on ClinicalTrials.gov |
What this trial studies
This interventional comparison gives one of two ultrasound-guided regional nerve blocks (costotransverse foramen block or erector spinae plane block) to women undergoing modified radical mastectomy to manage postoperative pain. Participants receive the allocated block along with standardized perioperative anesthesia and analgesia. Primary outcomes include postoperative pain scores and opioid consumption, with monitoring for block-related complications in the immediate and early postoperative period. The goal is to determine whether one technique leads to lower pain and analgesic requirements than the other.
Who should consider this trial
Good fit: Adult women aged >18 and ≤65 years with ASA physical status I–III and BMI 18–35 kg/m2 who are scheduled for modified radical mastectomy are the intended participants.
Not a fit: Patients with contraindications to regional anesthesia (local anesthetic allergy, infection at the injection site, coagulopathy or on anticoagulants), severe organ disease, morbid obesity, or severe cognitive impairment are excluded and unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the better-performing block could reduce postoperative pain and opioid use after mastectomy, speeding recovery and improving arm and chest function.
How similar studies have performed: Erector spinae plane block has shown reductions in postoperative pain and opioid use in prior reports, while the costotransverse foramen block is a newer inter-transverse process technique with limited outcome data so far.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult females \> 18 years and ≤ 65 years old. * American Society of Anesthesiologists (ASA) physical status П-III. * Body mass index (BMI) 18-35 kg/m2. * Scheduled for modified radical mastectomy. Exclusion Criteria: * Known allergy or hypersensitivity to local anesthetic agents. * Active infection at the injection site (e.g., cellulitis, abscess). * Coagulopathy or ongoing anticoagulant/antiplatelet therapy \[International Normalized Ratio (INR) \> 1.5 or platelet count \< 100,000/µL\]. * Severe respiratory, cardiac, hepatic, or renal disease. * Morbid obesity. * Severe cognitive impairment or uncooperative behavior that could interfere with block placement.
Where this trial is running
Cairo
- Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Mai M Elrawas, MD
- Email: mai.elrawas@nci.cu.edu.eg
- Phone: 00201222177242
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.