Study on mitochondrial health and vascular issues in Black adults
Mitochondria Dysfunction as a Contributor to Racial Disparities in Vascular Health and Hypertension
NA · Auburn University · NCT05561556
This study is testing if a supplement called MitoQ can improve blood vessel health and lower heart disease risk in Black adults aged 45-75 who are more likely to have high blood pressure and heart problems.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 45 Years to 75 Years |
| Sex | All |
| Sponsor | Auburn University (other) |
| Locations | 1 site (Auburn, Alabama) |
| Trial ID | NCT05561556 on ClinicalTrials.gov |
What this trial studies
This study investigates the relationship between mitochondrial dysfunction and vascular health, particularly focusing on Black adults aged 45-75 who are at heightened risk for cardiovascular diseases (CVDs) and hypertension. Participants will receive an intervention with MitoQ over an 8-week period to assess its effects on oxidative stress and vascular function. The study aims to address the significant racial disparities in hypertension and CVD outcomes by exploring whether targeting mitochondrial health can improve vascular function and reduce CVD risk. The findings could provide insights into effective interventions for a population disproportionately affected by these health issues.
Who should consider this trial
Good fit: Ideal candidates for this study are Black adults aged 45-75 with controlled blood pressure and no significant metabolic or cardiovascular diseases.
Not a fit: Patients with a history of cardiovascular disease, diabetes, or renal disease, as well as those with high blood pressure above 150/90 mmHg, will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved vascular health and reduced cardiovascular disease risk among Black adults.
How similar studies have performed: While there is ongoing research into mitochondrial dysfunction and cardiovascular health, this specific approach targeting Black adults with hypertension is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Are between the ages of 45-75 * Have blood pressure no higher than 150/90 mmHg * Have a BMI less than 40 Kg/m2 (otherwise healthy) * Free from metabolic disease (diabetes or renal disease), pulmonary disorders (e.g., COPD \& cystic fibrosis), and cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular) * Free of any medical issues that prevent participants from exercising (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis), giving blood (i.e., blood thinners), or allergies associated with MitoQ substances. Exclusion Criteria: * Known allergy to MitoQ * High blood pressure - greater the 150/90 mmHg * Low blood pressure - less than 90/50 mmHg * History of cardiovascular disease * History of cancer * History of diabetes * History of kidney disease * Obesity (BMI \> 40 kg/m2) * Current pregnancy * Nursing mothers * Communication barriers
Where this trial is running
Auburn, Alabama
- Auburn University — Auburn, Alabama, United States (RECRUITING)
Study contacts
- Principal investigator: Austin T Robinson, PhD — Kinesiology Building
- Study coordinator: Austin T Robinson, PhD
- Email: ausrobin@iu.edu
- Phone: 334 844 1619
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cardiovascular Diseases, Hypertension, Racism, Vascular Diseases, Cardiovascular health, Health disparities, Renal function, Vascular health