Study of early coronary artery disease in young adults in Pakistan

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The PAKistan Study of prEmature coronary atHerosclerosis in young AdulTs (PAK-SEHAT) is a prospective cohort study aimed at understanding the prevalence and severity of subclinical coronary atherosclerosis among young-to-middle aged Pakistani men and women who are free of clinical cardiovascular disease (CVD). The study will enroll 2,000 participants and follow them for 5 years to assess cardiovascular risk factors such as diabetes, hypertension, and dyslipidemia. By identifying the determinants of early coronary atherosclerosis, the study seeks to fill critical gaps in knowledge regarding cardiovascular health in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Native Pakistani
* Men aged 35-60 years \& women aged 35-65 years
* Willing to consent to participation

Exclusion Criteria:

eGFR \< 60 ml/min/1.73m2

Pregnant women

History of stroke or MI (CABG or PCI)

History of Peripheral arterial disease

Weight more than 102 Kg

Any active malignancy

Known contraindication from contrast used in cardiac CTA

Expected migration from residential area within 5 years

Where it's running

• Tabba Heart Institute
  Karachi, Sindh, Pakistan Recruiting

Study contacts

• Study coordinator: Bashir Hanif, FSCAI
• Email: bashir.hanif@tabbaheart.org
• Phone: +92-21-36811841

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.