SPSIP Block for Postoperative Recovery After Breast Cancer Surgery
Official title: Effects of Serratus Posterior Superior Intercostal Plane Block on Perioperative Inflammatory Response and TLR4-Mediated Innate Immune Activation in Breast Cancer Surgery: A Prospective, Randomized, Double-Blind, Sham-Controlled Trial
Run by Erol Olcok Corum Training and Research Hospital · NCT07843212 · Data updated 2026-11-12
This study tests whether giving an ultrasound-guided SPSIP block during breast cancer surgery helps reduce pain and inflammation compared with a sham procedure.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | Women only |
| Enrollment | 80 (estimated) |
| Sponsor | Erol Olcok Corum Training and Research Hospital Academic / other |
| Locations | 1 site (Çorum, Çorum) |
| Status | Recruiting |
| Started | June 22, 2026 |
| Main results expected | January 30, 2027 |
| Study ends | January 30, 2027 |
| Registry record updated | October 21, 2026 |
| Trial ID | NCT07843212 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18–85 scheduled for elective breast cancer surgery under general anesthesia with ASA I–III and no contraindications to regional anesthesia.
✕Probably not a fit
Patients with chronic pain, regular opioid use, coagulation disorders, infections at the injection site, or allergies to local anesthetics may not benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this randomized, sham-controlled trial, female adults undergoing elective breast cancer surgery under general anesthesia will receive either an ultrasound-guided serratus posterior superior intercostal plane (SPSIP) block or a sham procedure. All participants will receive standard anesthesia and postoperative pain management, and researchers will measure pain levels, need for extra pain medications, nausea, length of hospital stay, and pain at 3 months. Blood samples will be taken before surgery and at several postoperative times to assess inflammatory and immune markers, including Toll-like receptor 4. The goal is to see if the SPSIP block modulates the inflammatory response and improves recovery after surgery.
Why it matters
Potential benefit: If successful, the SPSIP block could reduce postoperative pain and inflammation, potentially speeding recovery and shortening hospital stays.
How similar studies have gone: Prior research in regional anesthesia suggests blocks can reduce postoperative pain and inflammatory responses in similar surgeries, but this exact SPSIP approach in breast cancer patients is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female patients aged 18 to 85 years. * Scheduled for elective breast cancer surgery under general anesthesia. * American Society of Anesthesiologists (ASA) physical status I-III. * Able to provide written informed consent. Exclusion Criteria: * Refusal to participate or inability to provide informed consent. * Allergy or contraindication to the study local anesthetic. * Coagulopathy or ongoing anticoagulant treatment contraindicating regional anesthesia. * Infection at the planned injection site. * Pre-existing chronic pain condition or regular opioid use. * Inability to communicate pain scores or comply with study assessments.
Where it's running
-
Hitit University Erol Olçok Training and Research Hospital
Çorum, Çorum, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Mucahide Emine Fidancı Kuas, MD
- Email: efidanci02@gmail.com
- Phone: +90-553-204-9918
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.