Spinal (intrathecal) morphine versus local bupivacaine for recovery after laparoscopic hysterectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In a prospective, randomized, double-blind design, patients undergoing elective laparoscopic hysterectomy are assigned to receive either 200 µg intrathecal morphine before general anesthesia or trocar-site infiltration plus intraperitoneal bupivacaine during surgery, with all patients managed under a standardized anesthetic protocol. The primary patient-centered outcome is the Quality of Recovery (QoR-15) score, with additional measurement of postoperative pain scores, opioid consumption, opioid-related side effects, and hematologic inflammatory markers. Respiratory and hemodynamic monitoring is emphasized after intrathecal morphine, and follow-up assessments occur during the immediate postoperative period. The trial directly compares a central neuraxial analgesic technique with peripheral local-anesthetic approaches to identify which strategy best supports early recovery after minimally invasive hysterectomy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female patients aged 18-65 years.
* Elective laparoscopic hysterectomy planned for benign gynecological conditions.
* American Society of Anesthesiologists (ASA) physical status I-III.
* Ability to provide written informed consent.

Exclusion Criteria:

* Coagulopathy or bleeding disorders.
* Opioid dependence or chronic opioid use.
* Allergy or contraindication to local anesthetics or morphine.
* Contraindication to neuraxial (spinal) anesthesia.
* History of chronic pain syndromes.
* Severe renal or hepatic dysfunction.
* Pregnancy or breastfeeding.

Where it's running

• Ataturk University
  Erzurum, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Ayşenur Dostbil, Principal Investigator — Ataturk University Department of Anesthesiology and Reanimation
• Study coordinator: Ayşenur Dostbil, Associate Professor
• Email: adostbil@hotmail.com
• Phone: +90-533-367-66-96

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.