Speech-based test to estimate relapse risk in psychosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, observational, multicenter project that collects weekly speech recordings and brief self-reports from people with psychosis at risk of relapse and from healthy controls over 12 months. Data are collected in six languages (English, German, French, Dutch, Czech, Turkish) through a smartphone app and securely transferred for AI-driven analysis. Human-in-the-loop reviewers check audio and transcripts and provide quality control while automated algorithms generate relapse risk scores that are stored but not shared with treating clinicians. The work aims to test feasibility, usability, and preliminary predictive markers across diverse healthcare settings without changing patient care during the study.

Why it matters

Who can join: the full rules

Healthy participants Inclusion Criteria:

* Between 18 and 65 years old.
* Subjects must be able to provide informed consent (IC).
* Participants must have provided signed informed consent prior to enrollment.
* Participants should not take prescription drugs regularly.
* Native or equivalent fluency in speaking and understanding one of the following languages: English, German, Dutch, French, Czech or Turkish.
* Ability to have access to a smartphone and be capable of using a mobile app for speech-based data collection.
* Must be able to comply with the study schedule and procedures.

Healthy participants Exclusion Criteria:

* Any history of major diseases (e.g., cardiovascular, neurological, metabolic, renal, hepatic, respiratory or speech disorders).
* Recreational drug use or psychiatric disorders due to use of alcohol.
* Depression, anxiety, or other psychiatric disorders.
* Family history of depression, anxiety, or other psychiatric disorders.
* Individuals who are not able or willing to understand the purpose and details of the study.

Individuals with psychosis Inclusion Criteria:

* Between 18 and 65 years old.
* Diagnoses include psychotic disorders (schizophrenia, schizoaffective disorder, schizophreniform disorder, acute psychosis, bipolar disorder with psychotic symptoms, psychosis not otherwise specified).
* First visit must be during remission phase (baseline measurement).
* Current positive symptoms rated 3 (mild) or lower on all of these Brief Psychiatric Symptom Scale (BPRS) items: hallucinatory behavior, unusual thought content, conceptual disorganization.
* Must be able to comply with the study schedule and procedures.
* Subjects must be able to provide IC.
* Participants must have provided signed informed consent prior to enrollment.
* Native or equivalent fluency in speaking and understanding one of the following languages: English, German, Dutch, French, Czech or Turkish.
* Ability to have access to a smartphone and be capable of using a mobile app for speech-based data collection.

Individuals with psychosis Exclusion Criteria:

* Severe comorbid speech disorders (aphasia or severe stuttering) that prevent adequate speech recording.
* Individuals who are not able or willing to understand the purpose and details of the investigation.

Citizens with psychiatric or somatic comorbidity, drug- or alcohol abuse will be allowed to participate, so that the sample will reflect the general population of citizens with psychosis and the study's endpoints will be generalizable.

Where it's running

• Psychiatric University Hospital Zurich and University of Zurich
  Zurich, Switzerland Recruiting
• National Institute of Mental Health
  Klecany, Czechia Not yet recruiting
• Newcastle Hospital and RCSI University of Medicine and Health Sciences
  Greystones, Wicklow, Ireland Not yet recruiting
• University Medical Center Groningen
  Groningen, Netherlands Not yet recruiting
• The Arctic University of Norway
  Tromsø, Norway Active not recruiting
• University Hospital Geneva and University of Geneva
  Geneva, Chêne-Bourg, Switzerland Not yet recruiting

Study contacts

• Study coordinator: Philipp Homan, Prof. Dr. med. univ. PhD
• Email: philipp.homan@bli.uzh.ch
• Phone: +41 58 384 33 65

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Changing Lives and Changing Outcomes-9 group program at Worcester Recovery Center and Hospital

  This program will try a nine-session cognitive-behavioral group to help adults with serious mental illness who have current or past legal involvement increase mental health awareness and lower chances of future legal problems.

  Recruiting Massachusetts General Hospital · Worcester, Massachusetts · NCT07359157

• Deprescribing antipsychotics using multiple real patient cases

  This project will see if reducing or stopping long-term antipsychotics works for adults with stable psychotic disorders by following real-world cases.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07343193

• Cognitive Strategies in Early Psychosis 2 – how brain games and pills test decision making

  This study tests whether a single dose of modafinil or d-serine, compared with placebo, changes decision making in people aged 18–35 who have recently begun experiencing psychosis.

  Recruiting Phase 3 University of Minnesota · Minneapolis, Minnesota · NCT07263022

• Long-term supervised exercise program to improve fitness and quality of life for inpatients with psychosis

  This program tries a long-term supervised exercise routine, including Pilates, to see if it improves physical function and quality of life for adults hospitalized with psychotic disorders.

  Recruiting Aristotle University Of Thessaloniki · Thessaloniki, Thermi · NCT07113119

• iTEST: a blended mobile program to improve introspective accuracy (accurate self-judgment of abilities)

  This trial tests whether iTEST — daily mobile cognitive training plus coaching that focuses on accurate self-judgment — helps adults with schizophrenia-spectrum or other psychotic disorders improve community functioning.

  Recruiting at 3 sites University of California, San Diego · San Diego, California and 2 other locations · NCT07098169

• Connectivity-guided theta-burst stimulation targeting the hippocampus in schizophrenia

  We will try targeted theta-burst TMS guided by brain connectivity to change hippocampus activity in adults with schizophrenia or related psychotic disorders, measuring brain signals with EEG and, for some participants, intracranial electrodes.

  Recruiting Stanford University · Stanford, California · NCT07010614

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.