Southeast Asian Brugada Syndrome Group

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort in Thailand collects demographic, clinical, ECG, and genetic data from Brugada syndrome patients and healthy controls. Researchers perform whole genome sequencing and SNP arrays to identify genetic variants, and then compare findings between cases and controls. Patients are followed over time to monitor symptoms and implantable cardioverter-defibrillator shocks, with analyses linking genetic variants to clinical severity. The study aims to clarify how genetics may influence BrS presentation and prognosis in Southeast Asian populations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Thai nationality
* The patient has at least one of confirmed Brugada type 1 ECG in at least one of right precordial leads (v1 or v2) with or without pharmacologic provocative testing. The confirmed ECG is standard 12 lead ECG or Brugada lead

Exclusion Criteria:

* The patient has other cardiac diseases such as ischemic heart disease, valvular heart disease, congenital heart disease, myocarditis and pericarditis
* The patient has type 2 or type 3 Brugada ECG without type 1 ECG during pharmacologic provocative testing and/or Brugada lead
* The patient had one time of Brugada type 1 ECG during drug use without reproducibility

Where it's running

• Bangkok Hospital
  Bangkok, Bangkok, Thailand Recruiting
• Siriraj Hospital, Mahidol University
  Bangkok Noi, Bangkok, Thailand Recruiting
• Vajira Hospital
  Dusit, Bangkok, Thailand Recruiting
• Chulalongkorn University
  Pathum Wan, Bangkok, Thailand Recruiting
• Faculty of Medicine Ramathibodi Hospital, Mahidol University
  Ratchathewi, Bangkok, Thailand Recruiting
• Bhumibol Adulyadej RTAF Hospital
  Sai Mai, Bangkok, Thailand Recruiting

Study contacts

• Principal investigator: Apichai Khongphatthanayothin, MD — Chulalongkorn University
• Study coordinator: Apichai Khongphatthanayothin, MD
• Email: apichaik@yahoo.com
• Phone: 66891555545

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Registry for patients with Brugada Syndrome at UZ Brussel

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• Using cheek (buccal) cells to detect cell-junction protein changes in inherited arrhythmias

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.