Long-term outcomes for patients with cardiac arrhythmias
Official title: Longterm Outcome and Predictors for Recurrence After Medical and Interventional Treatment of Arrhythmias At the University Heart Center Hamburg
Run by Universitätsklinikum Hamburg-Eppendorf · NCT05521451 · Data updated 2026-11-12
This study looks at how well treatments for heart rhythm problems work over time and what factors might affect their success for patients with conditions like atrial fibrillation and ventricular tachycardia.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 5000 (estimated) |
| Sponsor | Universitätsklinikum Hamburg-Eppendorf Academic / other |
| Locations | 1 site (Hamburg) |
| Status | Recruiting |
| Started | March 17, 2021 |
| Main results expected | September 30, 2026 |
| Study ends | December 31, 2031 |
| Registry record updated | March 30, 2025 |
| Trial ID | NCT05521451 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with diagnosed cardiac arrhythmias or those at high risk for developing them.
✕Probably not a fit
Patients who are not proficient in the German language or those unable to cooperate due to physical or psychological issues may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The TRUST study is a prospective cohort study that focuses on patients with cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia, treated at the University Heart Center Hamburg. It aims to collect comprehensive clinical, procedural, and outcome data to better understand the long-term effects and predictors of recurrence after treatment. The study will utilize systematic biobanking and digital capture of clinical information to enhance patient phenotyping and follow-up. This approach allows for a thorough analysis of the disease burden associated with arrhythmias in an aging population.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies and better management of cardiac arrhythmias, ultimately enhancing patient outcomes.
How similar studies have gone: Other studies focusing on the long-term outcomes of cardiac arrhythmias have shown promise, indicating that this approach could yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Cardiac arrhythmia, including congenital cardiac arrhythmia diagnosed at baseline or high risk for cardiac arrhythmia * Age ≥ 18 years * Written informed consent * Ability to provide written informed consent in accordance with Good Clinical Practice and local legislation Exclusion Criteria: * Insufficient knowledge of the German language to understand study documents and interview without translation * Physical or psychological incapability to cooperate in the investigation
Where it's running
-
University Hospital Hamburg-Eppendorf, University Heart and Vascular Center
Hamburg, Germany Recruiting
Study contacts
- Principal investigator: Paulus Kirchhof, MD — Universitätsklinikum Hamburg-Eppendorf
- Study coordinator: Julius Obergassel, MD
- Email: trust@uke.de
- Phone: +49 (40) 7410 - 58320
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Registry for hereditary cardiovascular diseases in Brazil
This study is trying to create a registry of Brazilian patients with hereditary heart diseases to see how common certain genetic changes are in people with these conditions.
-
Evaluating different approaches to cardiac pacing in patients
This study is testing different ways to place pacemakers in adults to see which methods work best and are safest for patients needing heart support.
-
Evaluating Atrial Fibrosis as a Predictor for Post-operative Atrial Fibrillation in Cardiac Surgery Patients
This study is trying to see if the amount of atrial fibrosis in patients can help predict if they will have heart rhythm problems after heart surgery.
-
Volta AI software in real-world AF ablation
A real-world observational study will test the latest Volta AF-Xplorer II AI software during atrial fibrillation ablation to see how safe and effective it is over 24 months.
-
HeartBeam ECG Registry: See How Heartbeat Patterns Look Across People
This registry tests HeartBeam ECG recordings in real-world patients to build a de-identified database for research.
-
Using the VERAFEYE imaging and navigation system to guide catheter ablation for atrial arrhythmias
This study will try the VERAFEYE imaging and guidance system during catheter ablation in adults with atrial flutter or atrial fibrillation to see if it integrates well with standard procedures.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.