Social isolation and aging in people with schizophrenia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project uses an accelerated longitudinal design that combines data collected when participants were 20–55 with new follow-up assessments now that they are 40–70. Participants must have a DSM-IV or DSM-5 schizophrenia-spectrum diagnosis, be clinically stable, and have enrolled in a prior study at least five years earlier. Researchers will measure social contact, clinical features, and physical-health markers linked to accelerated aging to examine their long-term relationships. No treatments are given; data collection occurs at participating sites in the US and Europe.

Why it matters

Who can join: the full rules

Inclusion and exclusion criteria for participants with SZ:

* DSM-IV or V diagnosis of a SZ related disorder (295.x, 297.1, 298.8, or 298.9; e.g., schizophrenia, schizoaffective disorder, schizophreniform disorder, but not psychotic disorder that is solely substance induced) based on clinical interview;
* Between 40 and 70 years of age at time of study recruitment;
* Participant was enrolled in a previous research study between the ages of 20-55, and this study took place at least 5 years ago;
* Able to understand the spoken language of the participating country sufficiently to comprehend testing procedures;
* No history of serious head injury (i.e., loss of consciousness longer than 1 hour, no neuropsychological sequelae, no cognitive rehabilitation treatment post head injury);
* No history of IQ \< 70, or developmental disability based on chart review;
* Clinically stable (i.e., no inpatient hospitalizations for three months prior to enrollment, no changes in medication in the four weeks prior to enrollment;

The inclusion and exclusion criteria for sibling participants in this study will be:

* No history of any DSM IV/V Axis I or axis II diagnosis that is known to be associated with social functioning (e.g. severe mood disorder, schizoaffective personality disorder, autism spectrum disorder);
* Between 40 and 70 years of age at time of study recruitment;;
* Participant was enrolled in a previous research study between the ages of 20-55, and this study took place at least 5 years ago;
* Able to understand the spoken language of the participating country sufficiently to comprehend testing procedures;
* No history of serious head injury (i.e., loss of consciousness longer than 1 hour, no neuropsychological sequelae, no cognitive rehabilitation treatment post head injury);
* No history of IQ \< 70, or developmental disability based on chart review;
* Clinically stable (i.e., no inpatient hospitalizations for three months prior to enrollment, no changes in medication in the four weeks prior to enrollment

Where it's running

• Olin Neuropsychiatry Research Center, Hartfort
  Hartford, Connecticut, United States Recruiting
• AUMC, University Hospital
  Amsterdam, North Holland, Netherlands Recruiting
• Hospital General Universitario Gregorio Marañon
  Madrid, Spain Recruiting
• King's College London
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: Abraham Reichenberg — Icahn School of Medicine at Mount Sinai
• Study coordinator: Eva Velthorst, PhD
• Email: e.velthorst@ggz-nhn.nl
• Phone: +31618644345

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.