Sitting ventilated ICU patients in an armchair to improve recovery.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will compare early armchair positioning with a conservative in-bed positioning strategy in adult ICU patients who have been invasively ventilated for more than 24 hours. Eligible patients are medically stable (RASS > -3), expected to remain in the ICU at least 48 hours, and have not previously been placed in a chair during the current stay. The intervention moves patients out of the resuscitation bed into an armchair as part of early mobilization, and outcomes focus on functional recovery and muscle performance. Clinical course and functional measures will be tracked to determine whether armchair positioning adds benefit over staying in bed.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patient \> 18 years old
2. Patient on invasive mechanical ventilation for more than 24 hours
3. Patient in recovery phase with a RASS score greater than "-3" for more than 12 hours
4. Stay expected to last 48 hours
5. Patient has never been placed in a chair during this hospitalization in intensive care.
6. Fragility score \< 6, during the month preceding admission to intensive care
7. Patient (or support person/relative if patient is unable to participate) who has agreed to take part in the study.

Exclusion Criteria:

1. Patient with an absolute and non-resolving contraindication to chair positioning

   1. Fracture or orthopedic disorder contraindicating mobilization out of bed
   2. Obesity with body mass index greater than 45 kg/cm2
   3. Sacral eschar stage greater than 2
2. Patient using a wheelchair for mobility (i.e. paraplegic patient or patient with progressive neurological pathology).
3. Patient treated with veno-venous or veno-arterial ECMO at the time of screening.
4. Moribund patient
5. Encephalic death
6. Acute polyradiculoneuritis (Guillain-Barré syndrome)
7. Myasthenia
8. Patient treated by continuous hemodialysis or hemofiltration for more than 72 hours following the onset of awakening.
9. Complete transmetatarsal or higher amputation of one or both lower limbs.
10. Protected person (under guardianship or curatorship)
11. Person under court protection
12. Person not affiliated to a social security scheme
13. Pregnant or breast-feeding woman
14. Patient already included in the study
15. Patient taking part in an interventional clinical study, the aim of which is to show an improvement in functional level on discharge from the intensive care unit or which focuses on the theme of early rehabilitation in the intensive care unit.

Where it's running

• Centre Hospitalier Universitaire d'Orléans
  Orléans, Centre-Val de Loire, France Recruiting
• Hopital Nord Franche Comte
  Belfort, France Recruiting
• CHU Clermont Ferrand
  Clermont-Ferrand, France Recruiting
• CHU de DIJON
  Dijon, France Recruiting
• CH Chartres
  Le Coudray, France Recruiting
• Ch Du Mans
  Le Mans, France Recruiting

Study contacts

• Principal investigator: Guillaume FOSSAT — CHU Orléans
• Study coordinator: Guillaume FOSSAT
• Email: guillaume.fossat@chu-orleans.fr
• Phone: +33238651318

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.