Short course of low‑dose heparin to prevent postpartum blood clots

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase 3 interventional study compares a short 7–10 day course of low‑dose low‑molecular‑weight heparin (LMWH) to no anticoagulation in postpartum women who meet specified risk-factor thresholds. Participants will receive LMWH or no treatment and be followed for 90 days after delivery to capture symptomatic venous thromboembolism, bleeding events, and wound complications. Women requiring therapeutic anticoagulation, judged high risk for postpartum VTE, with increased bleeding risk, or with contraindications to heparin are excluded. The primary outcomes are VTE within 90 days and the balance of bleeding and wound complications between arms.

Why it matters

Who can join: the full rules

Inclusion Criteria: postpartum women after delivery AND ≥1 major risk factor / ≥2 minor risk factors:

* Major risk factors: Emergency cesarean section ; Pre-pregnancy BMI ≥35kg/m2 ; Known low-risk thrombophilia (heterozygous factor V Leiden; heterozygous G20210 prothrombin mutation) ; Pre-eclampsia ; Pre-term delivery ; Peripartum systemic infection ; Intra-uterine growth restriction ; Pregnancy loss
* Minor risk factors: Age ≥35 years ; Pre-pregnancy BMI 30.0-34.9kg/m2 ; Current smoking ; Elective cesarean section ; Postpartum hemorrhage ; Antenatal immobility

Exclusion Criteria:

* ≥2 doses of postpartum LMWH
* Any indication for therapeutic anticoagulation
* A high-risk of postpartum VTE
* An increased bleeding risk
* A contra-indication to heparin

Where it's running

• Kantonsspital Baden
  Baden, Switzerland Recruiting
• Universitätsspital Basel
  Basel, Switzerland Recruiting
• Lindenhofspital
  Bern, Switzerland Recruiting
• Geneva University Hospitals
  Geneva, Switzerland Recruiting
• Centre Hospitalier Universitaire Vaudois
  Lausanne, Switzerland Recruiting
• Luzerner Kantonspital
  Lucerne, Switzerland Recruiting

Study contacts

• Study coordinator: Marc Blondon
• Email: marc.blondon@hug.ch
• Phone: (+41).22.372.92.92

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Smartphone-supported single-session psychotherapy for postpartum depression

  A single online therapy session plus four weeks of app-based support is being tested to see if it reduces depressive symptoms in postpartum women compared with a waitlist.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07925762

• Aspirin vs. rivaroxaban for blood clot prevention in newly diagnosed multiple myeloma

  In newly diagnosed multiple myeloma patients on IMiD-based therapy, this study tests whether aspirin or rivaroxaban is better at preventing blood clots.

  Recruiting Phase 4 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT07907211

• TRiP-cast score test in adults with acute lower-limb injuries requiring immobilization

  This study tests whether the TRiP(cast) score can predict risk of blood clots in adults with acute lower-limb injuries treated as outpatients.

  Recruiting University of Monastir · Monastir · NCT07863115

• Pulmonary Embolism Registry from Emergency Care to Long-Term Follow-Up

  This registry follows adults with acute pulmonary embolism to see how care is given in the real world and what happens over time.

  Recruiting at 16 sites Azienda Ospedaliero-Universitaria Careggi · Bagno a Ripoli, Tuscany and 15 other locations · NCT07855679

• Reducing Chronic Pain After Cesarean Delivery

  A single-session pain-relief class called Empowered Relief is tested alongside standard postpartum care to see if it helps women who have ongoing pain after cesarean delivery.

  Recruiting Stanford University · Palo Alto, California · NCT07799883

• Doula-delivered postpartum support with nurse coordination for people with preterm births in the NICU

  This trial tests whether doula-delivered postpartum help, guided by nurses, improves health outcomes and experiences for people with babies under 34 weeks in the NICU, compared to standard postpartum care.

  Recruiting University of South Carolina · Columbia, South Carolina · NCT07787845

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.