Severe Complications During VT/PVC Ablation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects patient-level data from multiple centers to characterize characteristics, procedural details, and subsequent management of severe complications arising from VT/PVC ablation. It includes adults undergoing VT/PVC ablation, with a focus on events like hemodynamic collapse, tamponade, stroke, or other major complications. Data are gathered from participating centers and linked over time through unique patient identifiers. No specific intervention is being tested; the aim is to describe past events and their outcomes to inform future practice. The study involves centers in the United States and Europe and is led by a Swiss university hospital with collaboration from several major academic centers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Centers : Centers participating in the present collaborative study group. Invitation to participate will be based either upon personal referral of one of the investigator, previous collaboration or based on a meta-analytic review of the literature published on the subject within the past 20 years.
* Patients: Females and males of \>18 years undergoing any type of VT/PVC ablation. While we will accept redo-procedure we will ask for a unique patient-identifier to link procedures belonging to the same patients together.
* Interventions: VT/PVC ablation (first intervention or re-do) as routinely performed by the participating centers
* Outcomes: Severe complications, defined as hemodynamic instability requiring mechanical intensive-care management, tamponade, stroke, cardiac arrest, myocardial infarction, phrenic nerve palsies, major bleeding requiring transfusion, vascular or cardiac complication requiring surgery, procedure-related death.
* Setting: Observational cohort studies, registries, retrospective cohort studies. Data stemming from RCTs (Randomized controlled trials) will not be collected as they likely do not represent a "real-life" setting.
* Length of follow-up: Peri-procedural complications
* Years considered: Not limited to a specific time-frame, but to reflect common ablation practices, we will focus on data from the 20 past years.
* Number of patients provided : No lower limit of patients provided per dataset or ablation volume per year to include high- as well as low-volume centers

Exclusion Criteria:

* Refusal of the center to participate.
* Less than 10 procedures available in the dataset (no case reports)
* Missing essential baseline characteristics, missing collection of sufficient details regarding each complication.

Where it's running

• Rush University Medical Center
  Chicago, Illinois, United States Recruiting
• University of Michigan
  Michigan Center, Michigan, United States Recruiting
• Medical University of Graz
  Graz, Austria Recruiting
• Université Laval
  Québec, Canada Recruiting
• The First Affiliated Hospital of Nanjing Medical University
  Nanjing, China Recruiting
• University Hospital Center Sestre milosrdnice
  Zagreb, Croatia Recruiting

Study contacts

• Principal investigator: Michael Kühne, Prof. Dr. med. — University Hospital, Basel, Switzerland
• Study coordinator: Michael Kühne, Prof. Dr. med.
• Email: Michael.kuehne@usb.ch
• Phone: 0041 61 265 52 14

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Risk of malignant arrhythmias after acute coronary syndrome

  This study tracks how often dangerous heart rhythms occur in adults admitted for ACS and looks for patterns that might predict them.

  Recruiting Catharina Ziekenhuis Eindhoven · Eindhoven, North Brabant · NCT07824050

• Targeted ablation to block scar channels that cause ventricular tachycardia

  This study tests whether targeted radiofrequency ablation of scar-channel exits can prevent ventricular tachycardia in patients with scarred hearts.

  Recruiting New York Medical College · Valhalla, New York · NCT07814079

• Predict Arrhythmia Risk with Intelligent Software

  Researchers are testing AI-powered predictions to see if clinicians can spot patients at risk for dangerous heart rhythms using bedside ECG data.

  Recruiting Catharina Ziekenhuis Eindhoven · Eindhoven, North Brabant · NCT07792694

• Non-invasive mapping to help treat ventricular tachycardia due to heart disease

  This study tests a non-invasive mapping tool to guide VT ablation in adults with structural heart disease and prior heart attack.

  Recruiting at 2 sites University of Warwick · Brighton and 2 other locations · NCT07759427

• Personalised VT substrate mapping with dynamic voltage mapping during ablation

  A procedure study to see if using dynamic voltage mapping during VT ablation helps identify and treat scar-related electrical circuits in people with ventricular tachycardia.

  Recruiting Liverpool Heart and Chest Hospital NHS Foundation Trust · Liverpool · NCT07573579

• Catheter ablation vs. anti-arrhythmic drugs for PVCs

  This study tests whether catheter ablation or anti-arrhythmic medications are better at reducing PVC symptoms and improving quality of life for adults with a normal heart function.

  Recruiting Western Sydney Local Health District · Westmead, New South Wales · NCT07445334

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.