SEPS vs Open Ligation for Varicose Veins in the Leg

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 18–70 with advanced chronic venous insufficiency and incompetent perforating veins will be randomized to receive SEPS or open perforator ligation. The trial will compare recovery, complications, and post-surgical outcomes between the two approaches. It uses standard surgical anesthesia and follows patients to assess short- and medium-term results. The goal is to determine which procedure provides better symptom relief and healing with fewer issues.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18-70 years.
* Diagnosed with lower limb varicose veins with incompetent perforating veins confirmed by duplex ultrasonography.
* CEAP clinical classification C4-C6 (advanced chronic venous insufficiency).
* Fit for elective surgery under spinal or general anesthesia.

Exclusion Criteria:

* Recurrent varicose veins after previous interventions.
* Deep vein thrombosis (DVT) or extensive deep venous obstruction.
* Severe systemic comorbidities contraindicating surgery.
* Patients unwilling to provide informed consent

Where it's running

• King Edward Medical University(KEMU), Lahore
  Lahore, Punjab Province, Pakistan Recruiting

Study contacts

• Principal investigator: Muhammad Usman, MBBS — King Edward Medical University (KEMU) Lahore
• Study coordinator: Muhammad Usman, MBBS
• Email: m.usman1320@gmail.com
• Phone: +923124010222

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.