Broccoli sprout extract and high-intensity exercise do they change immunometabolism in healthy adults?
Official title: Independent and Combined Effects of Short-term Sulforaphane Supplementation and Exercise on Immunometabolism in Healthy Adults: A Randomized Crossover Study
Run by University of British Columbia · NCT07668596 · Data updated 2026-11-12
This study tests whether taking broccoli sprout extract, doing short bursts of high-intensity exercise, or both, for four days affects markers of immunometabolism and inflammation in healthy young adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 19 Years to 35 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | University of British Columbia Academic / other |
| Locations | 1 site (Kelowna, British Columbia) |
| Status | Recruiting |
| Started | March 1, 2026 |
| Main results expected | December 1, 2027 |
| Study ends | June 1, 2028 |
| Registry record updated | July 17, 2026 |
| Trial ID | NCT07668596 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults aged 19–35 who are non-smokers, physically active, and free of cardiometabolic or certain respiratory diseases, with BMI ≤ 30 kg/m2.
✕Probably not a fit
Individuals with cardiometabolic diseases, respiratory diseases, high BMI, recent infection or vaccination, recent blood donation, pregnancy, or contraindications to high-intensity exercise may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants complete three interventional periods in random order, each separated by at least a 1-week washout. One period tests four days of broccoli sprout extract supplementation, another tests four days of supervised high-intensity treadmill running, and the third combines both interventions. Before and after each period, researchers measure body metrics and collect blood to analyze metabolic and inflammatory markers. The study uses a randomized crossover design to compare the individual and combined effects within the same individuals.
Why it matters
Potential benefit: If successful, the study could identify simple lifestyle strategies to favorably modulate immunometabolic and inflammatory responses.
How similar studies have gone: Similar interventions have shown biological effects in related areas, but this exact combination and crossover design is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * aged between 19 and 35 years * not a current smoker * physically active based on the Canadian Physical Activity Guidelines (150 minutes of weekly physical activity) Exclusion Criteria: * a history of cardiometabolic diseases or respiratory diseases (e.g., chronic obstructive pulmonary disease, asthma, diabetes, coronary artery disease) * currently following a ketogenic diet * body mass index (BMI) over 30 kg/m2 * unable to read or communicate in English * having received a vaccination or experienced an upper respiratory tract infection in the last 4 weeks * having donated more than 0.5 L of blood within the last 4 weeks * currently pregnant * have contraindications to high intensity exercise (assessed using the CSEP Get Active Questionnaire)
Where it's running
-
Reichwald Health Sciences Centre
Kelowna, British Columbia, Canada Recruiting
Study contacts
- Study coordinator: Hashim Islam Principle Investigator, Ph.D
- Email: hashim.islam@ubc.ca
- Phone: 250-807-9122
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.