See if hypotension during anesthesia induction relates to tissue oxygen in open-heart surgery
Official title: Investigation of the Relationship Between Hypotension and Tissue O2 in Invasive Eadyn During Anesthesia Induction in Open Heart Surgery: Observational Study
Run by Haseki Training and Research Hospital · NCT07831252 · Data updated 2026-11-12
This study tests whether post-induction hypotension in open-heart surgery patients can be predicted using arterial and tissue oxygenation measures.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Haseki Training and Research Hospital Academic / other |
| Locations | 1 site (Istanbul, Sultangazi) |
| Status | Recruiting |
| Started | September 1, 2025 |
| Main results expected | December 17, 2026 |
| Study ends | December 17, 2026 |
| Registry record updated | September 21, 2026 |
| Trial ID | NCT07831252 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (ASA I–III) planned for open-heart surgery without the listed exclusions.
✕Probably not a fit
Patients with preexisting conditions or emergencies not represented in the cohort may not benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study monitors adults undergoing open-heart surgery to see if post-induction hypotension correlates with tissue oxygenation in the brain and kidneys. Participants will be tracked from just before anesthesia through ten minutes after induction, with data on Eadyn, cerebral and renal regional saturation, and vasopressor responses collected. Patients will be grouped by the presence or absence of hypotension, and standardized monitoring will ensure consistent data capture. The aim is to understand how arterial load and tissue oxygenation interact during induction and whether this can help predict or prevent hypotension and related organ effects.
Why it matters
Potential benefit: If successful, findings could improve prediction and prevention of hypotension during anesthesia, potentially reducing organ injury risk.
How similar studies have gone: Previous research has explored predictors of post-induction hypotension, with novel measures like Eadyn showing promise, but this specific arterial-ventricular interaction in induction is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: • American Society of Anaesthesiologists (ASA) Physical Status classification I to III • Patients who planned open heart surgery Exclusion Criteria: • Age \< 18 years * Presence of arrhythmia (atrial fibrillation or frequent premature beats) * Severe valvular heart disease (aortic or mitral stenosis/insufficiency) * Severe heart failure (EF \< 40%) * Congenital heart disease * Severe chronic lung disease * Chronic kidney disease requiring dialysis * Severe peripheral vascular disease * Morbid obesity * Emergency surgery cases
Where it's running
-
Haseki Educational and Research Hospital
Istanbul, Sultangazi, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Muhammet A Gök, Medical Doctor — Haseki Educational and Research Hospital
- Study coordinator: Muhammet A Gök, Medical Doctor
- Email: drmuhammetaligook@gmail.com
- Phone: +9005393824171
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
See if virtual reality headsets can help with pain and anxiety after open-heart surgery
This randomized trial tests whether using virtual reality headsets after open-heart surgery reduces pain and anxiety and improves satisfaction and physiological measures compared with standard care.
-
Box breathing before chest tube removal after open-heart surgery
This trial tests whether performing a 5-minute box breathing session before chest tube removal reduces pain, anxiety, and breathlessness in adults who had open-heart surgery.
-
Does fasting time affect post-induction low blood pressure after anesthesia?
This observational study tests whether how long a patient fasts before anesthesia changes the chance of post-induction hypotension in adults undergoing planned procedures.
-
Wearable activity to see if daily movement predicts perioperative risk in older adults
This study tests whether preoperative activity measured by a wrist-worn accelerometer can help predict post-induction hypotension in adults aged 65 and older undergoing elective non-cardiac surgery.
-
Predicting Post-Induction Hypotension in Elderly Patients Using Baroreflex Sensitivity and Machine Learning
Researchers are testing a machine learning approach that uses baroreflex sensitivity and other preoperative data to predict the risk of post-induction hypotension in people over 65 undergoing elective non-cardiac surgery.
-
Protamine dose options to reverse heparin after open‑heart bypass
This trial will test three different protamine dosing ratios (1:1, 0.8:1, and 0.75:1) to see which safely and effectively reverses heparin in adults having elective open‑heart surgery with cardiopulmonary bypass.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.