Predicting Post-Induction Hypotension in Elderly Patients Using Baroreflex Sensitivity and Machine Learning

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-center cohort study will combine preoperative dynamic baroreflex sensitivity metrics—measured with continuous non-invasive arterial pressure—and static clinical features to build a predictive model for post-induction hypotension in elderly patients. Multiple algorithms, including Logistic Regression, Random Forest, gradient boosting methods, XGBoost, LightGBM, and LSTM, will be explored and validated with cross-validation. The study aims to improve individualized risk stratification to support intraoperative management under general anesthesia. Enrollment targets 500 participants aged over 65 with ASA I–III undergoing elective non-cardiac surgery. Data will integrate preoperative autonomic indices, frailty assessments, intraoperative events, and 30-day postoperative outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged over 65 years;
* Scheduled for elective non-cardiac surgery;
* American Society of Anesthesiologists (ASA) physical status classification I-III;
* Planned for general anesthesia with endotracheal intubation;
* Patient and legal guardians are capable of understanding the study protocol and willing to provide written informed consent.

Exclusion Criteria:

* Severe peripheral vascular diseases;
* Secondary hypertension;
* Presence of physical tremors (e.g., Parkinson's disease) preventing stable recording;
* Inability to accurately measure upper limb blood pressure;
* Pre-existing cardiac arrhythmias (e.g., atrial fibrillation) that render BRS;
* Psychiatric disorders or cognitive impairments hindering basic cooperation.

Where it's running

• Peking Union Medical College Hospital
  Beijing, China, China Recruiting

Study contacts

• Study coordinator: Quexuan Cui, Dr.
• Email: Cuiqx_garfield@126.com
• Phone: +8613520921711

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.